Table 3.
Clinical outcomes of neonates infected by SARS-CoV-2.
| Author; Country | Gestational age (w) | Birthweight (g) | Delivery | Symptoms | Pneumonia | Lymphopenia/ Thrombocytopenia | Increased CRP/PCT | Treatment | NICU admission | Mechanical ventilation | CPAP/ NIPPV | Duration of respiratory support (days) | Sepsis | Shock | Inotropes | Neonatal death | Follow-up (days) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yu N.; China | 40 | 3250 | Cesarean | SOB | Yes | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 40 |
| Zamaniyan M; Iran | 30.7 | 2350 | Cesarean | Fever | No | NR/NR | NR/NR | Ampicillin, gentamicin | Yes | No | No | – | No | No | No | No | 7+ |
| Alzamora MC; Peru | 33 | 2970 | Cesarean | Cough, SOB | No | NR/NR | NR/NR | No | Yes | Yes | CPAP | 0.5 | No | No | No | No | 6+ |
| Wang S; China | 40 | 3205 | Cesarean | No | Yes | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 15 |
| Dong L; China | 37.7 | 3120 | Cesarean | No | No | No/No | No/NR | No | Yes | No | No | – | No | No | No | No | 25 |
| Zeng L; China | 40 | 3250 | Cesarean | Fever | Yes | No/No | No/Yes | NR | Yes | No | No | – | No | No | No | No | 6+ |
| 40.6 | 3360 | Cesarean | Fever | Yes | Yes/No | NR/NR | NR | No | No | No | – | No | No | No | No | 6+ | |
| 31.3 | 1580 | Cesarean | SOB | Yes | Yes/No | NR/NR | NR | Yes | No | NIPPV | 14 | Yes | No | No | No | 14+ | |
| Aghdam MK; Iran | NR | 3460 | Cesarean | Fever, cough | No | No/No | No/NR | Vancomycin, amikacin, oseltamivir | Yes | No | No | – | Yes | No | No | No | 14+ |
| Zhang ZJ; China | 40 | NR | Cesarean | SOB | Yes | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | NR |
| NR | NR | Cesarean | Fever, cough, vomiting | Yes | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 23 | |
| NR | NR | Cesarean | Fever | No | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 30 | |
| 40.1 | NR | Cesarean | No | Yes | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 16 | |
| Coronado Munoz; USA | 36 | NR | NR | Nasal congestion, SOB, feeding intolerance | Yes | No/No | Yes/Yes | Ampicillin, gentamycin, vancomycin, cefepime, hydroxychloroquine, azithromycin | Yes | Yes | No | 5 | Yes | Yes | Yes | No | 9 |
| Khan S; China | 40.6 | 3360 | Cesarean | NR | No | NR/NR | NR/NR | NR | NR | NR | NR | NR | NR | NR | NR | No | NR |
| 39.1 | 3570 | Cesarean | NR | Yes | NR/NR | NR/NR | NR | NR | NR | NR | NR | NR | NR | NR | No | NR | |
| Hu X; China | 40 | 3250 | Cesarean | No | No | No/No | No/No | No | No | No | No | – | No | No | No | No | NR |
| Salvatori G; Italy | 41.3 | 4440 | NR | No | No | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | NR |
| 39 | 3120 | NR | Cough, diarrhea | No | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 5+ | |
| Alonso Diaz C; Spain | 38.6 | 2500 | Cesarean | SOB | Yes | NR/NR | No/NR | No | Yes | No | No | – | No | No | No | No | 13 |
| Zeng LK; China | 39 | NR | NR | Fever, SOB, vomiting | Yes | No/No | No/Yes | No | No | No | No | – | No | No | No | No | 7 |
| Wang J; China | 38.6 | 3030 | Vaginal | Fever, cough, vomiting | Yes | No/Yes | No/No | Interferon | No | No | No | – | No | No | No | No | 14 |
| Xiaoyuan F; China | NR | NR | NR | Fever, vomiting | No | NR/NR | NR/NR | Antimicrobial | No | No | No | – | No | No | No | No | 16 |
| NR | NR | NR | Vomiting | No | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 16 | |
| NR | NR | NR | Diarrhea, vomiting | Yes | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 15 | |
| NR | NR | NR | Fever | Yes | NR/NR | NR/NR | Antimicrobial | No | No | No | – | No | No | No | No | 13 | |
| NR | NR | NR | Feeding intolerance | Yes | NR/NR | NR/NR | No | No | No | No | – | No | No | No | No | 7 |
NR: not reported; CRP: C-reactive protein; PCT: procalcitonin; NICU: neonatal intensive care unit; CPAP: continuous positive airway pressure; NIPPV: noninvasive positive pressure ventilation; SOB: shortness of breath.