Table 3.

Veno-venous ECMO survival prediction instruments.

Prediction instrument	Primary disease	Patients in derivation cohort	Predictors included	Internal validation (AUROC)	External validation (AUROC)
ECMOnet 2012 [36]	ARDS in suspected Influenza A (H1N1)	60 from 14 Italian hospitals	Pre-ECMO LOS, MAP, Bilirubin, Creatinine, Hematocrit	0.86	0.69 [36] 0.604 [32] 0.695 [35] 0.554 [62]
PRESERVE 2013 [31]	ARDS	140 patients from 3 French hospitals	Age, BMI, Immunocompromise, SAPS II, Prone positioning, MV duration, Plateau Pressure, PEEP	0.89	0.685 [32] 0.75 [63] 0.593 [35] 0.64 [37]
Roch et al. [33]	ARDS	85 patients at single French center	Age, SOFA score, Influenza	0.80	0.564 [35] 0.619 [62]
RESP 2014 [34]	Severe acute respiratory failure	2355 from ELSO database	Age, immunocompromise, diagnosis, CNS dysfunction, Non-pulmonary infection, bicarbonate infusion, Cardiac Arrest, MV duration, NMB, iNO, PaCO2, PIP	0.74	0.92 [31] 0.81 [63] 0.645 [35] 0.835 [62] 0.69 [37]
PRESET 2017 [35]	ARDS	108 from single German center	Pre-ECMO LOS, MAP, Admission, arterial pH, Lactate, Platelet count	0.845 [0.76–0.93]	0.70

Abbreviations: ECMO, extracorporeal membrane oxygenation; AUROC, area under the receiver operating characteristics curve; ARDS, acute respiratory distress syndrome; LOS, length of stay; MAP, mean arterial pressure; MV, mechanical ventilation; PEEP, positive end expiratory pressure; SOFA, sequential organ failure assessment; ELSO, Extracorporeal Life Support Organization; CNS, central nervous dysfunction; NMB neuromuscular blockade; iNO, inhaled nitric oxide; PaCO2, arterial content of carbon dioxide; PIP, peak inspiratory pressure.