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Main reported roles and mechanisms involving leaky gut and intestinal microbiota changes for the treatment of liver disease. Abbreviations: IRAK1, Interleukin 1 Receptor Associated Kinase 1; LPS, lipopolysaccharide; MyD88, Myeloid differentiation primary response 88; SCFA, short-chain fatty acids; TLR4, toll-like receptor 4; TNF-α, tumor necrosis factor-alpha; TRIF, TIR-domain-containing adapter-inducing interferon-β.
