Table 1.

A list of lncRNAs involved in cholesterol metabolism, efflux, and associated disease.

LncRNA	Target	Findings	Ref
Cholesterol metabolism
Lnc-HC	hnRNPA2B1, Cyp7a1, Abca1	Lnc-HC-hnRNPA2B1 complex decreases Cyp7a1, Abca1	[41]
	miR-130b-3p, PPARγ	Negatively regulates PPARγ expression via miR-130b-3p	[40]
BM450697	LDLR	Regulates and local scaffold for LDLR transcription	[45]
HOXC-AS1	HOXC6	Promotes HOXC6	[50]
HULC	ASCL1, PPARA	miR-9/PPARA/ACSL1/cholesterol/RXRA/HULC signaling.	[43]
AT102202	HMGCR	Regulates HMGCR expression	[48]
LASER	PCSK9	Feedback HNF-1α/PCSK9 and LXR dependent pathway	[47]
RP1-13D10.2	LDLR	Regulates LDLR and contributes to LDLC’s response to statin	[46]
RP5-833A20.1	miR-382-5p, NFIA	RP5-833A20.1/miR-382-5p/NFIA pathway	[37]
DAPK-IT1	miR-590-3p, LPL	DAPK1-IT1/hsa-miR-590-3p/LPL axis	[38]
Lnc-KDM5D-4		Key processes related to fatty liver a	[51]
NEAT1	miR-342-3p	Regulates lipid uptake through modulating miR-342-3p	[39]
LeXis	RALY	Binds to RALY to express cholesterol synthetic genes	[42]
LncARSR	SREBP-2, HMGCR	Hepatic cholesterol biosynthesis via Akt/SREBP-2/HMGCR	[49]
Cholesterol efflux
DYN-LRB2-2	TLR2, ABCA1	Upregulates cholesterol efflux by ABCA1 expression	[52]
ENST00000602558.1	ABCG1	Regulates ABCG1 expression through binding to p65	[53]
ZFAS1	miR-654-3p, ADAM10, RAB22A	Elevates ADAM10/RAB22A expression to reduce cholesterol efflux in a miR-654-3p-dependent way	[54]
CDKN2B-AS1	ADAM10	Promotes cholesterol efflux by inhibiting ADAM10	[55]
CHROME	miR-27b, 33a, 33b, 128	Promotes cholesterol efflux and hepatic HDL biogenesis	[56]
MeXis	Abca1	LXR-dependent transcription of Abca1	[57]
AC096664.3	ABCG1, PPAR-γ	Regulates ABCG1 expression via inhibiting PPAR-γ	[58]
MALAT1	miR-17-5p, ABCA1	MALAT1/miR-17-5p/ABCA1 axis	[59]
Disease
TUG1	miR-92a, ApoM, ABCA1, ABCG1	Regulates ApoM, ABCA1 and ABCG1 expression, and attenuates cholesterol efflux via the miR-92a/FXR1 axis	[60]
MEG3	PTBP1	Cholestasis by recruiting PTBP1 to destabilize Shp mRNA	[61]
LncAP001033.3-201	ITGB3, TBXA2R	Associated with low HDL-C disease and could play a role in platelet activation in cardiovascular disease	[62]
LncAC068234.2-202
Brip1os, Gm16586, AU020206,9430034N14Rik,2510016D11Rik, LNC000709, Gm15472, Gm20703, Dubr	Cdk4, Eif2ak2, Ccna2, Ccne1, Ccnd3, Mdm2, Nfkbia, Bax, Pkm, Pik3cb, Jak1, Lyn, Hdac9	Potential therapeutic targets for atherosclerosis (AS) via an ox-low-density lipoprotein induced macrophage-derived foam cell model	[63]
ENST00000416361	SREBP-1, SREBP-2	Associated with CAD-induced lipid metabolism	[64]
ANRIL, MALAT1	rs9632884 rs1537373, rs619586 rs3200401	Genetic variation of the ANRIL rs9632884 and MALAT1 rs3200401 mediates lipid levels in MI patients	[65]
TUG1	miR-133a, FGF1	TUG1 modulates FGF1 via miR-133a	[66]