Fig. 1.

SARS-CoV genome organization and expression. Genome (top), products of genome translation (left) and transcription (right) are shown. ORFs and polyprotein regions are colored according to their predominant function (see inset). Genome ORFs are depicted in their frame, with ORF1a frame set to zero. For each sg mRNA, only ORFs believed to be translated from it are shown, without indicating their frame relative to ORF1a. For genome and sg mRNAs, RNA signals are indicated by color (see inset). For polyproteins, autoproteolytic processing scheme (see inset) and selected protein domains (see text for abbreviations) are specified. The NC_004718.3 record was used to prepare this figure. Note that sg mRNA 3.1 [55] is not shown; the most N-terminal ubiquitin (Ub) and Macro domains are separated by acidic, structurally disordered region of ∼70 aa [56,57]. SUD-N and SUD-M, N-terminal and Middle domains of SARS-CoV Unique Domain, respectively [58,59]; Y, Y domain [57].