Table 2.
Mixed linear models. Differences in laboratory parameters between times of the study according to delirium manifestation, during the hospitalization
| Patients without delirium | Patients with delirium | ||||||
|---|---|---|---|---|---|---|---|
| Baseline | FU | Baseline | FU | p1 | p2 | p3 | |
| 42 | 42 | 14 | 14 | ||||
| Red blood cell count (× 106/mm3) | 4.42 ± 0.75 | 4.21 ± 0.72 | 4.23 ± 0.76 | 4.01 ± 0.65 | 0.35 | 0.11 | 0.93 |
| Hemoglobin (g/dl) | 12.20 ± 2.32 | 11.98 ± 1.79 | 11.49 ± 2.42 | 11.04 ± 1.89 | 0.14 | 0.32 | 0.67 |
| White blood cell count (× 103/μl) | 8.57 ± 8.73 | 6.35 ± 2.20 | 9.23 ± 3.75 | 8.86 ± 3.59 | 0.14 | 0.84 | 0.41 |
| Neutrophils (× 103/μl) | 5.47 ± 3.63 | 3.90 ± 2.18 | 7.40 ± 3.65 | 6.65 ± 3.74 | 0.006 | 0.41 | 0.46 |
| Eosinophils (× 103/μl) | 0.04 ± 0.06 | 0.17 ± 0.15 | 0.03 ± 0.05 | 0.13 ± 0.12 | 0.12 | 0.01 | 0.33 |
| Lymphocytes (× 103/μl) | 1.18 ± 0.66 | 1.72 ± 0.68 | 1.05 ± 0.45 | 1.45 ± 0.72 | 0.16 | 0.007 | 0.37 |
| Monocytes (× 103/μl) | 0.87 ± 2.07 | 0.49 ± 0.19 | 0.71 ± 0.63 | 0.60 ± 0.45 | 0.78 | 0.81 | 0.60 |
| Platelet count (× 103/mm3) | 221.74 ± 81.41 | 222.46 ± 50.84 | 212.19 ± 82.64 | 221.25 ± 100.81 | 0.98 | 0.71 | 0.77 |
| Erythrocyte sedimentation rate (mm) | 40.13 ± 20.49 | 39.68 ± 20.94 | 33.55 ± 17.57 | 36.80 ± 18.42 | 0.54 | 0.71 | 0.69 |
| Reactive C protein (mg/dl) | 77.94 ± 73.75 | 20.11 ± 52.59 | 68.97 ± 50.72 | 66.34 ± 61.03 | 0.01 | 0.90 | 0.03 |
| Procalcitonin (ng/ml) | 2.13 ± 8.13 | 0.31 ± 1.14 | 0.40 ± 0.55 | 0.39 ± 0.60 | 0.96 | 0.99 | 0.38 |
| Prothrombin time (%) | 88.38 ± 26.81 | 93.30 ± 24.90 | 80.05 ± 18.81 | 80.23 ± 17.14 | 0.07 | 0.97 | 0.42 |
| INR | 1.28 ± 0.88 | 1.13 ± 0.30 | 1.18 ± 0.19 | 1.18 ± 0.20 | 0.75 | 0.99 | 0.37 |
| Activated partial thromboplastin time (s) | 38.30 ± 22.82 | 35.25 ± 15.44 | 36.11 ± 5.78 | 35.33 ± 5.68 | 0.99 | 0.80 | 0.52 |
| Fibrinogen (mg/dl) | 506.73 ± 148.30 | 450.20 ± 139.63 | 432.40 ± 166.22 | 382.73 ± 155.31 | 0.16 | 0.12 | 0.86 |
| D-dimer (μg/ml) | 2.23 ± 5.05 | 1.05 ± 1.34 | 1.73 ± 1.47 | 1.93 ± 1.44 | 0.43 | 0.87 | 0.35 |
| Glycemia (mg/dl) | 104.76 ± 23.53 | 93.57 ± 32.99 | 116.44 ± 39.60 | 100.44 ± 29.63 | 0.46 | 0.12 | 0.70 |
| Azotemia (mg/dl) | 55.68 ± 43.91 | 50.68 ± 48.05 | 77.25 ± 69.76 | 61.19 ± 63.85 | 0.51 | 0.11 | 0.36 |
| Estimated glomerular filtration rate | 86.58 ± 26.45 | 97.05 ± 20.05 | 90.34 ± 72.53 | 81.23 ± 88.19 | 0.41 | 0.60 | 0.28 |
| Creatinine (mg/dl) | 1.60 ± 2.15 | 1.20 ± 1.75 | 1.39 ± 1.33 | 1.34 ± 1.46 | 0.80 | 0.84 | 0.25 |
| Albumin (g/dl) | 3.73 ± 0.66 | 3.54 ± 0.82 | 3.16 ± 0.43 | 3.16 ± 0.43 | 0.09 | 0.99 | 0.35 |
| Troponin (pg/ml) | 28.85 ± 39.78 | 17.48 ± 23.07 | 23.36 ± 19.75 | 36.54 ± 52.07 | 0.19 | 0.34 | 0.12 |
| Sideremia (μg/dl) | 38.90 ± 22.23 | 37.24 ± 21.91 | 49.07 ± 77.05 | 51.93 ± 76.31 | 0.33 | 0.37 | 0.25 |
| Ferritin (ng/ml) | 679.08 ± 1071.80 | 532.60 ± 870.98 | 337.25 ± 232.57 | 337.25 ± 232.57 | 0.64 | 0.99 | 0.60 |
| Neutrophil/lymphocyte ratio | 6.02 ± 5.14 | 2.80 ± 2.61 | 9.37 ± 8.91 | 7.12 ± 7.67 | 0.01 | 0.18 | 0.62 |
For every parameter, the follow-up assessment (FU) was the last measurement available before discharge or transfer to long-term care unit. p value 1 = p value for the comparison between patients with and without delirium; p value 2 = p value for the comparison between the two times of the study; p value 3 = p value for the interaction between times of the study and presence or absence of delirium. Significant differences are highlighted in italicized character