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. 2018 Sep 17;11(9):e002115. doi: 10.1161/CIRCGEN.118.002115

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© 2018 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Associations of genetic variants in 7q22 with carotid intraplaque fat. Rs12539895 was previously associated with coronary artery disease (CAD; purple). The strongest association was for a deletion chr7:106901393 (triglycerides [TG] >T; P=2.14×10⁻⁷; pink). The x axis shows the chromosomal position relative to 1000G (March 2012, Hg19). The lower shows refSeq canonical genes from UCSC (the black arrow indicates the direction of transcription). The left y axis shows the −log₁₀(P value) of the association with intraplaque fat. The right y axis shows the recombination rate (gray line in the middle). The middle shows each associated variant colored by the r² relative to rs12539895. The legend in the upper right corner shows the r² color scale. The per variant annotation key is depicted in the bottom left corner. Made using LocusZoom version 1.3 and SNiPA.^19,20 COG5 indicates component of oligomeric Golgi complex 5; CpG, cytosine-guanine dinucleotide; eQTL, expression quantitative trait loci; HBP1, HMG-box transcription factor 1; and mQTL, methylation quantitative trait loci.