Figure 2.

Association of rs3815148 with HBP1 expression in carotid plaques. Rs3815148 is a proxy (LD r²=0.91) for rs12539895 and associated (P=7.0×10⁻⁶) with HBP1 expression in carotid plaques from BiKE. A, Regional association of variants with HBP1 expression in carotid plaques. The x axis shows the chromosomal position relative to 1000G (March 2012, Hg19) and refSeq canonical genes (green) from UCSC (the black arrow indicates the direction of transcription). The left y axis shows the −log₁₀ P value of the association with HBP1 expression. The right y axis shows the recombination rate (gray line). The middle shows each associated variant colored by the r² relative to rs12539895. The legend in the upper right corner shows the r² color scale. B, Boxplot of the association of rs3815148 with HBP1 expression. Proxy data based on 1000G phase 3, version 5 data from SNiPA.²⁰ Made using LocusZoom version 1.3.¹⁹