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. 2018 Sep 17;11(9):e002115. doi: 10.1161/CIRCGEN.118.002115

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© 2018 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Polygenic scores of coronary artery disease (CAD; dark pink) and large artery stroke (LAS; blue) associate with different plaque characteristics. Polygenic scores for CAD associate with intraplaque fat (A), whereas polygenic scores for LAS associate with intraplaque hemorrhage (B) and smooth muscle cells (C). Scores were constructed based on GWAS (Genome-Wide Association Study) summary statistics using increasingly liberal P value thresholds (P_T, see also Information in the Data Supplement; Table II in the Data Supplement). Each P_T bin is depicted on the x axis. The y axis indicate the r² of the association; please note the different scales. *P<0.05 for association of the score with the plaque characteristic. PGC indicates bipolar disorder from the Psychiatric Genetics Consortium (green).