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The inhibitory effects of compound 2e, celecoxib, and indomethacin on COX-1 and COX-2.
| Compound | IC50 (µM) | SI * | |
|---|---|---|---|
| COX-1 | COX-2 | ||
| 2e | 73.5 ± 2.12 | 37.5 ± 3.54 | 1.96 |
| Celecoxib | 8.875 ± 0.375 | 2.75 ± 0.05 | 3.23 |
| Indomethacin | 0.12 ± 0.01 | 0.575 ± 0.075 | 0.21 |
* SI = IC50 for COX-1/IC50 for COX-2.
