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. 2020 Nov 8;21(21):8371. doi: 10.3390/ijms21218371

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Th17 differentiation of naïve CD4+ T cells is inhibited by HWG-35D. Naïve CD4⁺ T cells isolated from the mouse spleen were polarized using differentiating media into Th1, Th2, and Th17 CD4⁺ T cells as described in the material and methods section. (A) IFN-γ, (B) IL-4, and (C) IL-17A levels secreted from differentiated CD4⁺ T cells were measured using ELISA. The mRNA expression levels of (D) SOCS1, (E) SOCS3, and (F) IL-17A were analyzed using real-time PCR in differentiated Th17 murine CD4⁺ T cells. Data are mean ± S.E.M. values (n = 6). * p < 0.05, ** p < 0.01, *** p < 0.001.