Table 2.
Recently reported upregulated miRNAs acting as oncomiRs in hepatocellular carcinoma (HCC).
| miRNA | Targets | Mechanism | Reference |
|---|---|---|---|
| miR-10b | CUB and sushi multiple domains 1 (CSMD1) | Division, migration, invasion | [109] |
| miR-21 | Kruppel like factors 5 (KLF1), Calmodulin regulated spectrin associated protein family member 1 (CAMSAP1), DEAD-box helicase 1 (DDX1), MARCKS like 1 (MARCKSL1) | Division, cell growth, migration, invasion |
[110,111] |
| miR-25 | TNF related apoptosis-inducing ligand (TRAIL) | Apoptosis | [112] |
| miR-92a | F-box and WD repeat domain containing 7 (FBXW7) | Proliferation, cell cycle transition, apoptosis | [113] |
| miR-96-5p | Caspase-9 | Apoptosis | [114] |
| miR-107 | High mobility group AT-hock 2 (HMGA2), 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) |
Cell growth, Epithelial-mesenchymal transition (EMT) |
[115,116] |
| miR-135a | Forkhead box O1 (FOX O1) | Migration, invasion | [117] |
| miR-155-5p | Phosphatase and tensin homolog (PTEN) | Proliferation, invasion, migration, apoptosis | [118] |
| miR-181a | Autophagy related 5 (ATG5) | Autophagy | [119] |
| miR-221 | P53, P53 upregulated modulator of apoptosis (PUMA), NF-κB, signal transducer and activator of transcription 3 (STAT3), adeno-associated virus serotype 8 (AAV8), PTEN, metalloproteinase inhibitor 3 (TIMP3), TRAIL | Apoptosis, proliferation | [37,38,39,40,120] |
| miR-203a-3p | Interleukin 24(IL-24) | Cell growth, metastasis | [121] |
| miR-210 | Fibroblast growth factor receptor like 1 (FGFRL1) | Angiogenesis | [122] |
| miR-214-5p | Wiskott-Aldrich syndrome like (WASL) | Invasion, migration | [123] |
| miR-302d | Transforming growth factor beta receptor 2 (TGFBR2) | Cell growth, invasion | [124] |
| miR-346 | F-box and leucine rich repeat protein 2 (FBXL2) | Proliferation, migration, invasion | [125] |
| miR-487a | EVH1 domain containing 2 (SPRED2) 2, phosphoinositide-3-Kinase regulatory 1 (PIK3R1) |
Proliferation, metastasis | [126] |
| miR-765 | Inositol polyphosphate-4-phosphatase type II B (INPP4B) | Proliferation | [127] |
| miR-873 | Tumor suppressor in lung cancer 1 (TSLC1) | Proliferation, migration, invasion | [128] |
| miR-892a | CD266 molecule | Proliferation, invasion | [129] |
| miR-1249 | Patched 1 (PTCH1) | Cell growth, migration, invasion | [130] |
| miR-1468 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 (CITED2), Up-frameshift protein 1 (UPF1) | Proliferation, apoptosis | [131] |
| miR-3910 | Macrophage stimulating 1 (MST1) | Cell growth, migration | [132] |
| miR-4417 | Tripartite motif containing 35 (TRIM35), pyruvate kinase muscle 2 (PKM2) |
Proliferation, apoptosis | [133] |