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. 2020 Nov 7;21(21):8362. doi: 10.3390/ijms21218362

Table 2.

Recently reported upregulated miRNAs acting as oncomiRs in hepatocellular carcinoma (HCC).

miRNA Targets Mechanism Reference
miR-10b CUB and sushi multiple domains 1 (CSMD1) Division, migration, invasion [109]
miR-21 Kruppel like factors 5 (KLF1), Calmodulin regulated spectrin associated protein family member 1 (CAMSAP1), DEAD-box helicase 1 (DDX1), MARCKS like 1 (MARCKSL1) Division, cell growth,
migration, invasion
[110,111]
miR-25 TNF related apoptosis-inducing ligand (TRAIL) Apoptosis [112]
miR-92a F-box and WD repeat domain containing 7 (FBXW7) Proliferation, cell cycle transition, apoptosis [113]
miR-96-5p Caspase-9 Apoptosis [114]
miR-107 High mobility group AT-hock 2 (HMGA2),
3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2)
Cell growth,
Epithelial-mesenchymal transition (EMT)
[115,116]
miR-135a Forkhead box O1 (FOX O1) Migration, invasion [117]
miR-155-5p Phosphatase and tensin homolog (PTEN) Proliferation, invasion, migration, apoptosis [118]
miR-181a Autophagy related 5 (ATG5) Autophagy [119]
miR-221 P53, P53 upregulated modulator of apoptosis (PUMA), NF-κB, signal transducer and activator of transcription 3 (STAT3), adeno-associated virus serotype 8 (AAV8), PTEN, metalloproteinase inhibitor 3 (TIMP3), TRAIL Apoptosis, proliferation [37,38,39,40,120]
miR-203a-3p Interleukin 24(IL-24) Cell growth, metastasis [121]
miR-210 Fibroblast growth factor receptor like 1 (FGFRL1) Angiogenesis [122]
miR-214-5p Wiskott-Aldrich syndrome like (WASL) Invasion, migration [123]
miR-302d Transforming growth factor beta receptor 2 (TGFBR2) Cell growth, invasion [124]
miR-346 F-box and leucine rich repeat protein 2 (FBXL2) Proliferation, migration, invasion [125]
miR-487a EVH1 domain containing 2 (SPRED2) 2,
phosphoinositide-3-Kinase regulatory 1 (PIK3R1)
Proliferation, metastasis [126]
miR-765 Inositol polyphosphate-4-phosphatase type II B (INPP4B) Proliferation [127]
miR-873 Tumor suppressor in lung cancer 1 (TSLC1) Proliferation, migration, invasion [128]
miR-892a CD266 molecule Proliferation, invasion [129]
miR-1249 Patched 1 (PTCH1) Cell growth, migration, invasion [130]
miR-1468 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 (CITED2), Up-frameshift protein 1 (UPF1) Proliferation, apoptosis [131]
miR-3910 Macrophage stimulating 1 (MST1) Cell growth, migration [132]
miR-4417 Tripartite motif containing 35 (TRIM35),
pyruvate kinase muscle 2 (PKM2)
Proliferation, apoptosis [133]