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. 2020 Oct 30;11:575469. doi: 10.3389/fendo.2020.575469

Table 3.

Imputed IL2RA genotypes and their significant associations with sIL-2R in plasma.

Chr SNP bp* Intron/Exon A1 n Beta (95% CI) p-Value
10 rs12722489 6102012 Intron 1 T 330 −0.28 (−0.39, −0.17) 5.19 × 10−7
10 rs12722517 6081040 Intron 1 C 330 −0.24 (−0.34, −0.14) 2.23 × 10−6
10 rs9663421 6055604 Intron 7 T 330 0.25 (0.15, 0.35) 3.17 × 10−6
10 rs12722553 6071284 Intron 1 A 330 −0.26 (−0.37, −0.15) 3.30 × 10−6
10 rs12722551 6071379 Intron 1 T 330 −0.26 (−0.37, −0.15) 3.30 × 10−6
10 rs791593 6083292 Intron 1 G 330 −0.23 (−0.33, −0.14) 4.22 × 10−6
10 rs2104286 6099045 Intron 1 C 330 −0.24 (−0.33, −0.14) 4.63 × 10−6
10 rs41294713 6080354 Intron 1 C 330 −0.25 (−0.36, −0.15) 5.23 × 10−6
10 rs12722515 6081230 Intron 1 A 330 −0.25 (−0.36, −0.15) 5.23 × 10−6
10 rs791590 6090322 Intron 1 T 330 −0.25 (−0.36, −0.15) 5.23 × 10−6
10 rs2246031 6092210 Intron 1 T 330 −0.25 (−0.36, −0.15) 5.23 × 10−6
10 rs7078614 6075831 Intron 1 T 330 −0.21 (−0.30, −0.12) 5.50 × 10−6
10 rs7920946 6074634 Intron 1 C 330 −0.22 (−0.31, −0.13) 5.53 × 10−6
10 rs4625363 6072504 Intron 1 G 330 −0.25 (−0.36, −0.15) 5.54 × 10−6
10 rs12722527 6077328 Intron 1 T 330 −0.25 (−0.36, −0.15) 5.54 × 10−6
10 rs12722523 6078390 Intron 1 A 330 −0.25 (−0.36, −0.15) 5.54 × 10−6
10 rs12722561 6069893 Intron 1 T 330 −0.25 (−0.36, −0.15) 6.22 × 10−6
10 rs12722559 6070273 Intron 1 A 330 −0.25 (−0.36, −0.15) 6.22 × 10−6
10 rs12722606 6053133 Exon 8 A 330 0.25 (0.14, 0.36) 6.98 × 10−6
10 rs11256335 6055222 Intron 7 A 330 0.25 (0.14, 0.36) 6.98 × 10−6
10 rs12722605 6053163 Exon 8 A 330 0.29 (0.17, 0.42) 7.27 × 10−6
10 rs12722497 6095928 Intron 1 A 330 0.35 (0.20, 0.50) 1.22 × 10−5
10 rs11256464 6082558 Intron 1 T 330 0.32 (0.18, 0.47) 2.55 × 10−5
10 rs11597237 6079017 Intron 1 T 330 −0.23 (−0.33, −0.12) 3.07 × 10−5
10 rs11256416 6075359 Intron 1 T 330 −0.21 (−0.31, −0.11) 3.67 × 10−5
10 rs7910961 6077796 Intron 1 T 330 0.20 (0.11, 0.30) 4.04 × 10−5
10 rs4747837 6058735 Intron 7 G 330 −0.23 (−0.34, −0.12) 4.34 × 10−5
10 rs7900385 6062748 Intron 4 A 330 −0.23 (−0.34, −0.12) 4.34 × 10−5
10 rs12722588 6060433 Intron 6 T 330 −0.22 (−0.33, −0.11) 5.83 × 10−5
10 rs12722587 6060630 Intron 6 T 330 −0.22 (−0.33, −0.11) 5.83 × 10−5
10 rs7093069 6063319 Intron 4 T 330 −0.22 (−0.33, −0.11) 5.83 × 10−5
10 rs11816044 6074082 Intron 1 A 330 0.20 (0.10, 0.30) 8.91 × 10−5
10 rs7100984 6078539 Intron 1 A 330 0.20 (0.10, 0.30) 9.07 × 10−5
10 rs12722574 6066462 Intron 2 A 330 −0.20 (−0.29, −0.10) 9.63 × 10−5
10 rs4749894 6058323 Intron 7 G 330 0.22 (0.11, 0.33) 1.00 × 10−4
10 rs4749924 6082396 Intron 1 C 330 0.20 (0.10, 0.29) 1.00 × 10−4
10 rs6602398 6082953 Intron 1 T 330 0.20 (0.10, 0.29) 1.00 × 10−4
10 rs7900744 6065611 Intron 3 G 330 −0.20 (−0.29, −0.10) 1.19 × 10−4
10 rs791588 6089342 Intron 1 G 330 0.15 (0.06, 0.24) 7.71 × 10−4
10 rs11256342 6057231 Intron 7 G 330 0.17 (.07, 0.26) 8.37 × 10−4
10 rs12253981 6092346 Intron 1 G 330 0.16 (0.07, 0.25) 8.84 × 10−4
10 rs2025345 6067688 Intron 2 G 330 0.16 (0.07, 0.26) 9.75 × 10−4
10 rs12358961 6066195 Intron 3 A 330 0.16 (0.07, 0.26) 1.03 × 10−3
10 rs1924138 6096158 Intron 1 A 330 0.16 (0.06, 0.25) 1.06 × 10−3
10 rs11256497 6087794 Intron 1 A 330 0.15 (0.06, 0.25) 1.36 × 10−3
10 rs10795752 6072354 Intron 1 T 330 0.15 (0.06, 0.25) 1.51 × 10−3
10 rs2245675 6095577 Intron 1 A 330 0.16 (0.06, 0.25) 1.55 × 10−3
10 rs2256852 6096923 Intron 1 A 330 0.16 (0.06, 0.25) 1.55 × 10−3
10 rs791587 6088699 Intron 1 A 330 0.14 (0.05, 0.23) 1.62 × 10−3
10 rs12251836 6091281 Intron 1 A 330 0.15 (0.06, 0.24) 1.65 × 10−3
10 rs6602368 6062915 Intron 4 C 330 0.15 (0.06, 0.24) 1.67 × 10−3
10 rs2476491 6095410 Intron 1 T 330 0.16 (0.06, 0.26) 1.74 × 10−3
10 rs4749926 6085312 Intron 1 A 330 0.15 (0.05, 0.24) 2.60 × 10−3
10 rs11256457 6080794 Intron 1 G 330 0.15 (0.05, 0.24) 2.72 × 10−3
10 rs10905641 6072293 Intron 1 C 330 0.14 (0.05, 0.23) 3.41 × 10−3
10 rs6602379 6073374 Intron 1 G 330 0.14 (0.05, 0.24) 3.51 × 10−3
10 rs809356 6091148 Intron 1 C 330 0.13 (0.04, 0.22) 3.60 × 10−3
10 rs2256774 6097165 Intron 1 C 330 0.14 (0.05, 0.23) 3.87 × 10−3
10 rs1323657 6072427 Intron 1 A 330 0.13 (0.04, 0.23) 3.95 × 10−3
10 rs7072398 6079846 Intron 1 A 330 0.13 (0.04. 0.22) 5.33 × 10−3
10 rs10795763 6096199 Intron 1 G 330 0.13 (0.04. 0.22) 5.34 × 10−3
10 rs7917726 6096600 Intron 1 G 330 0.13 (0.04. 0.22) 5.34 × 10−3
10 rs706779 6098824 Intron 1 C 330 0.12 (0.03. 0.21) 7.97 × 10−3
10 rs10905656 6086093 Intron 1 A 330 0.11 (0.02. 0.20) 1.51 × 10−2
10 rs3793713 6059704 Intron 7 G 330 0.11 (0.01. 0.20) 2.56 × 10−2
10 rs4749920 6071453 Intron 1 C 330 0.11 (0.01. 0.21) 3.73 × 10−2
10 rs4749921 6071654 Intron 1 C 330 0.11 (0.01. 0.21) 3.73 × 10−2
10 rs4747845 6074441 Intron 1 A 330 0.11 (0.01. 0.21) 3.73 × 10−2

*SNP positions according to the Genome Reference Consortium Human Build 37 (GRch37).

Linear regression model: p-value = adjusted for age, sex and complication group. Chr, chromosome; SNP, single nucleotide polymorphism; bp, base pair; A1, minor allele; CI, confidence interval.