Table 4.
Association between acid suppressant combination and dementia risk.
| Acid Suppressant Combination Use | No. of Subjects | Dementia Development | Adjusted HR * (95% CI) | |
|---|---|---|---|---|
| No. of Cases | Incidence Rate (per 1000) | |||
| Neither | 23,277 | 4570 | 19.99 | 1.00 (Reference) |
| H2RA only | 15,534 | 3531 | 23.97 | 1.85 (1.26–2.16) |
| PPI only | 9036 | 1662 | 21.40 | 1.64 (1.14–1.92) |
| Concurrent use | 4994 | 865 | 20.57 | 1.23 (1.07–1.98) |
* CI, confidence interval; H2RA, histamine 2 receptor antagonist; HR, hazard ratio; PPI, proton pump inhibitor. * Hazard ratios were adjusted for sex, age, index year, Charlson comorbidity index, use of co-medications, including non-steroidal anti-inflammatory drugs and aspirin, and numbers of annual outpatient visits.