Table 2.
Spearman's rho correlation and multivariate linear regression analyses of circulating CLU estimates.
| Variables | Circulating CLU levels (μg/mL) | |||
|---|---|---|---|---|
| Spearman's rho correlation | Linear regressiona | |||
| Coefficient (r) | P-value | β coefficient (95% CI) | P-value | |
| Gender (male:female) | 0.12 | 0.24 | – | – |
| Age (years) | 0.11 | 0.28 | – | – |
| BMI (kg/m2) | 0.29 | 0.09 | – | – |
| Liver stiffness (kPa) | − 0.54 | < 0.001* | − 0.50 (− 0.71 to − 0.30) | < 0.001* |
| AST (IU/L) | − 0.44 | < 0.001* | − 0.08 (− 0.12 to − 0.03) | 0.003* |
| ALT (IU/L) | − 0.39 | < 0.001* | − 0.05 (− 0.10 to − 0.001) | 0.047* |
| ALP (IU/L) | − 0.37 | < 0.001* | − 0.02 (− 0.04 to − 0.01) | 0.01* |
| Albumin (g/dL) | 0.42 | < 0.001* | 4.45 (− 2.22 to 11.13) | 0.19 |
| TB (mg/dL) | − 0.45 | < 0.001* | − 1.64 (− 2.83 to − 0.44) | 0.008* |
| DB (mg/dL) | − 0.55 | < 0.001* | − 1.68 (− 2.92 to − 0.43) | 0.009* |
| Platelet (cells/m3) | 0.31 | 0.013* | 9.04 × 10–5 (0.00 to 0.00) | 0.002* |
| PT (s) | − 0.17 | 0.20 | – | – |
| PTT (s) | − 0.24 | 0.061 | – | – |
| APRI | − 0.46 | < 0.001* | 0.03 (− 1.58 to 2.12) | 0.77 |
| INR | − 0.27 | 0.035* | − 27.65 (− 75.00 to 19.70) | 0.25 |
ALP alkaline phosphatase, ALT alanine aminotransferase, APRI AST to platelet ratio index, AST aspartate aminotransferase, BA biliary atresia, BMI body mass index, DB direct bilirubin, INR international normalized ratio, PT prothrombin time, PTT partial thromboplastin time, TB total bilirubin, NA not available.
*Correlation is considered statistically significant at P-value less than 0.05 (two-tailed).
aThe coefficient was adjusted for gender, age, and BMI.