Table 2.

Top 17 candidate miRNAs identified in microarray analysis deregulated between ME/CFS and healthy matched controls.

miRNA	Fold difference
ME/CFS T0 versus CTRLS T0
hsa-miR-29a-3p	+ 2.00*
hsa-miR-150-5p	+ 2.86*
hsa-miR181b-5p	+ 2.77***
hsa-miR-4433a-5p	− 6.46***
hsa-miR-6819-3p	− 11.13***
ME/CFS T90 versus CTRLS T90
hsa-miR-127-3p	+ 2.86*
hsa-miR-140-5p	+ 3.74***
hsa-miR-150-5p	+ 2.93*
hsa-miR-374b-5p	+ 2.49***
hsa-miR-486-5p	− 2.13***
hsa-miR-3620-3p	− 2.47*
hsa-miR-5581-5p	+ 2.18*
hsa-miR-6076	+ 2.39*
hsa-miR-6507-3p	− 3.43*
hsa-miR-6717-5p	+ 3.68*
hsa-miR-6800-3p	− 2.88*
hsa-miR-6875-5p	+ 8.58*
ME/CFS T90 versus ME/CFS T0
hsa-miR-28-5p	+ 2.57***
hsa-miR-29a-3p	+ 1.98*
hsa-miR-140-5p	+ 2.79***
hsa-miR-374b-5p	+ 2.43**
hsa-miR-486-5p	− 2.03***
hsa-miR-6800-3p	− 2.65*
hsa-miR-6875-5p	+ 4.02*
CTRLS T90 versus CTRLS T0
hsa-miR-3620-3p	+ 3.72*
hsa-miR-6507-3p	+ 5.62*

MiRNA expression profile using microarray analysis at baseline and T90 of ME/CFS and healthy matched controls. The data is represented as a fold difference.

ANOVA was used to analyze the differences and measure the significance *P value < 0.05, **P value < 0.01, and ***P value < 0.001.