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. 2020 Nov 12;10:19617. doi: 10.1038/s41598-020-76824-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The anticancer effects of SA and ASA on a murine model of implanted melanoma. Panel a: design of the animal protocol. Panel b: representative pictures of the tumors extracted from untreated animals and those treated with SA or ASA. Panels c and d: tumors weight and tumors growth, respectively, comparing the control treatment with SA and ASA treatments. Panel e: average values for the mice body weight during the treatment. Panel f: average values for the activity of the liver enzymes AST and ALT in the serum of the animals. Values are mean ± S.E.M. of 8 different animals in each group (n = 8). * means P < 0.05 as compared to the control (One-way ANOVA followed by Dunnett post-test).