Table 3.

Association of FGF23 with Cardiac Function.

Measure of Cardiac Function	β coefficient per SD increase in FGF23 (95% CI)	P value
LV structure
LV mass
Model 1*	2.02 (1.04, 3.01)	<0.001
Model 2†	1.14 (0.16, 2.12)	0.02
LV function
Global circumferential strain
Model 1*	0.18 (0.08, 0.27)	<0.001
Model 2†	0.15 (0.05, 0.25)	0.003
Mid-wall circumferential strain
Model 1*	0.22 (0.11, 0.33)	<0.001
Model 2†	0.20 (0.08, 0.31)	0.001
Ejection fraction
Model 1*	−0.10 (−0.38, 0.19)	0.51
Model 2†	−0.20 (−0.51, 0.11)	0.21
Stroke Volume
Model 1*	0.35 (−0.27, 0.97)	0.27
Model 2†	0.37 (−0.30, 1.05)	0.28
LA Function
Total Emptying Fraction
Model 1*	−0.51 (−0.97, −0.05)	0.03
Model 2†	−0.52 (−1.02, −0.02)	0.04
Peak longitudinal strain
Model 1*	−0.41 (−0.98, 0.16)	0.16
Model 2†	−0.27 (−0.89, 0.36)	0.40

^*Adjusted for age, sex, race, and income at Exam 1

^†Adjusted for Model 1 covariates plus: smoking status, diabetes, systolic blood pressure, anti-hypertensive medication use, BMI, eGFR, LDL cholesterol, UACR, 25-hydroxyvitamin D, calcium, urine phosphate, and PTH at Exam 1

BMI = body mass index; eGFR = estimated glomerular filtration rate; FGF23 = fibroblast growth factor 23; LA = left atrial; LDL = low density lipoprotein; LV = left ventricular; PTH = parathyroid hormone; UACR = urinary albumin-to-creatinine ratio