Table 1.

Summary of experimental studies on liver regeneration after partial hepatectomy (PHx) of steatotic liver (separate file).

	Author	Published Year	Animal	Induction of Steatosis	Degree of Steatosis *	PHx	Evaluation of Liver Regeneration	Timing of Evaluation	Liver Regeneration
1	Zhang et al. [104]	1999	rats	MCDD for 4 weeks	Not mentioned	68%	Liver weight, [3H]-thymidine incorporation	24 h	Not impaired
2	Selzner et al. [105]	2000	rats	fa/fa rats, 20 weeks old	Severe	70%	Liver weight, mitotic index, BrdU, PCNA	24, 48, 96 h	Impaired
3	Rao et al. [106]	2001	rats	Choline-deficient diet for 4 weeks	Severe	70%	Mitotic index, BrdU	24, 36, 48, 72, 96 h	Not impaired
4	Yang et al. [107]	2001	mice	ob/ob mice, 8-10 weeks old	Severe	70%	BrdU, PCNA	24, 36 h	Impaired
5	Torbenson et al. [108]	2002	mice	ob/ob mice, 10 weeks old	Moderate	70%	BrdU	24, 36 h	Impaired
6	Picard et al. [109]	2002	rats	fa/fa rats, 13 weeks old	Moderate	70%	Liver weight, BrdU, PCNA(WB)	24 h	Impaired
				Orotic acid for 4 weeks	Severe				Not impaired
				MCDD	Severe				Not impaired
7	Yamauchi et al. [110]	2003	mice	db/db mice, 10 weeks old	Severe	70%	Liver weight, mitotic index, BrdU, PCNA	24, 48, 72, 120, 168, 240 h	Impaired
8	DeAngelis et al. [111]	2005	mice	High-fat diet, for 8-12 weeks	Severe	70%	Liver weight, BrdU	12, 24, 36, 48, 60, 72, 96, 120 h	Impaired
9	Tanoue et al. [112]	2011	rats	High-fructose diet for 4 weeks	Mild	70%	Liver weight, PCNA	24, 72, 168 h	Impaired
				High-fat diet for 4 weeks	Severe				Not impaired
10	Sydor et al. [113]	2013	mice	Western diet for 6 weeks	Mild	70%	Ki67, PHH3	24, 48, 168 h	Enhanced
11	Collin de l’Hortet et al. [114]	2014	mice	ob/ob mice, 13-14 weeks old	Severe	55%	Liver weight, mitotic index, BrdU, PHH3	32, 44, 56, 68 h	Impaired
				MCDD for 5 weeks	Severe				Delayed
12	Zimmers et al. [115]	2017	mice	High-fat diet for 11-13 weeks	Not mentioned	70% and 80%	Liver weight, BrdU, PCNA(WB)	6, 24, 48, 72, 96, 120 h	Impaired
13	Valdecantos et al. [116]	2017	mice	MCDD for 3 weeks §	Moderate	70%	Liver weight, BrdU, PCNA(WB)	48, 336 h	Impaired ‡
				High fat diet for 13 weeks §	Mild				Impaired

*: The degree of steatosis was subjectively assessed as mild: <30%, moderate: 30–60%, severe: >60%. ^§: Special diet was continued after hepatectomy. ^‡: BrdU uptake and PCNA expression were higher at 48 h after hepatectomy. BrdU, bromodeoxyuridine 5-bromo-2’-deoxyuridine; MCDD, methionine- and choline-deficient diet; PCNA, proliferating cell nuclear antigen; PHH3, phospho histone H3 staining.