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. 2020 Nov 9;21(21):8412. doi: 10.3390/ijms21218412

Figure 2.

Figure 2

The role of eotaxins in cancer. In a neoplastic cell there is an expression of CCL11 (eotaxin-1), CCL24 (eotaxin-2) and CCL26 (eotaxin-3). This increases the autocrine proliferation and causes the migration of cancer cells with CCR3 expression. Eotaxins also activate the CCR3 receptor on endothelial cells, which results in angiogenesis. Another effect of an increased expression of eotaxins in the tumor is the recruitment of cells into the tumor niche, in particular eosinophils, by all three eotaxins through the CCR3 receptor. MDSC are recruited into the tumor by CCL26 via CX3CR1.