Table 2.
Effects of increased expression of individual CC chemokine receptors discussed in this review on the prognosis of patients with various cancers according to “The Human Protein Atlas” (https://www.proteinatlas.org/) [8,9].
| Type of Cancer | Receptor | |||
|---|---|---|---|---|
| CCR1 | CCR2 | CCR3 | CCR4 | |
| Glioma | ↓p = 0.095 | ↓ | -- | -- |
| Thyroid cancer | -- | ↑ | -- | -- |
| Lung cancer | ↓p = 0.088 | ↑ | ↓ | ↑ |
| Colorectal cancer | -- | ↑ | -- | ↑ |
| Head and neck cancer | ↑p = 0.067 | ↑ | ↓ | ↑ |
| Stomach cancer | -- | -- | ↓ | -- |
| Liver cancer | -- | ↑p = 0.081 | ↓ | -- |
| Pancreatic cancer | -- | -- | ↓ | -- |
| Renal cancer | ↓ | ↓ | ↓ | ↓ |
| Urothelial cancer | -- | -- | ↓p = 0.098 | -- |
| Prostate cancer | -- | -- | ↑ | -- |
| Testicular cancer | ↓ | ↓ | ↓ | ↓ |
| Breast cancer | -- | ↑ | ↓ | ↑ |
| Cervical cancer | -- | ↑ | ↓ | ↑ |
| Endometrial cancer | -- | ↑ | ↓ | ↑ |
| Ovarian cancer | ↑ | ↑ | ↑ | ↑ |
| Melanoma | ↑ | ↑p = 0.063 | ↓ | ↑ |
↑ blue background—better prognosis with higher expression of a given chemokine in a tumor; ↓ red background—worse prognosis with higher expression of a given chemokine in a tumor; -- means no correlation with higher expression of a given chemokine in a tumor.