Table 1.
• Neutrophilic Inflammation |
• Reduced Bacterial Clearance and Alterations in Microbiome |
• Increased Matrix Metalloproteinase Activity and Gene Expression |
• Greater Oxidative Stress |
• Increased Apoptosis |
• Pulmonary Surfactant Deactivation |
• Reduced Mucociliary Clearance |
• Epigenetic Changes - DNA Damage and Methylation |
• Disruption of Lung Endothelial Cell Barrier |