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. 2020 Nov 12;6:122. doi: 10.1038/s41420-020-00355-2

Fig. 1. Mechanism of activated CD8+ T cells drives ferroptosis in tumor cells.

Fig. 1

The activated CD8+ T cells generate IFN-γ and TNF; afterward, IFN-γ binds to the extracellular domain IFN-gamma R1/R2, results in Jak1 and Jak2 activation, and then contributes to STAT1 phosphorylation. After STAT1 phosphorylation, its homodimerization and nuclear translocation promote IRF1; both SLC7A11 and SLC3A2 are inhibited. Subsequently, the glutamate–cystine antiporter system xc is impaired, eventually resulting in tumor cell ferroptosis.