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. 2020 Nov 12;10:19676. doi: 10.1038/s41598-020-76961-y

Table 2.

Critical errors for each inhaler device before and after education.

Critical steps of inhalation technique Any critical errors P-value
Before education (Visit 1) After education (Visit 3)
Turbuhaler, n = 20
Open the device correctly 0 (0) 0 (0)
Prime with device upright 9 (45.0) 1 (5.0) 0.003
Seal lips around mouthpiece during inhalation 0 (0) 0 (0)
Inhale forcefully or deeply 4 (20.0) 0 (0) 0.106
Breezhaler, n = 61
Open the device correctly 0 (0) 0 (0)
Place capsule in the chamber 1 (1.6) 0 (0) 1.000
Close the mouthpiece 5 (2.5) 0 (0) 0.057
Press button to pierce the capsule 13 (21.3) 0 (0)  < 0.001
Seal lips around mouthpiece during inhalation 0 (0) 0 (0)
Inhale forcefully or deeply 16 (26.2) 4 (6.6) 0.003
Remove capsule and check for powder residue 6 (9.8) 0 (0) 0.027
Ellipta, n = 36
Open the device correctly 2 (5.6) 1 (2.8) 1.000
Seal lips around mouthpiece during inhalation 0 (0) 0 (0)
Inhale forcefully or deeply 8 (22.2) 1 (2.8) 0.028
Diskus, n = 8
Open the device correctly 0 (0) 0 (0)
Pull the lever fully back 1 (12.5) 0 (0) 1.000
Seal lips around mouthpiece during inhalation 0 (0) 0 (0)
Inhale forcefully or deeply 0 (0) 0 (0)
Genuair, n = 18
Open the device correctly 0 (0) 0 (0)
Hold the inhaler horizontally (green button facing upwards) for priming 3 (16.7) 0 (0) 0.229
Seal lips around mouthpiece during inhalation 0 (0) 0 (0)
Inhale forcefully or deeply 6 (33.3) 0 (0) 0.019
Respimat, n = 145
Twist the base one half-turn 28 (19.3) 4 (2.8)  < 0.001
Open the device correctly 27 (18.6) 4 (2.8)  < 0.001
Seal lips around mouthpiece during inhalation 10 (6.9) 2 (1.4) 0.035
Synchronize actuation and inhalation 36 (24.8) 12 (8.3)  < 0.001
Inhale slowly and deeply 39 (26.9) 13 (9.0)  < 0.001
pMDI, n = 20
Open the device correctly 0 (0) 0 (0)
Shake well (suspension formulations only) 3 (15.0) 0 (0) 0.231
Keep inhaler upright 3 (15.0) 1 (5.0) 0.605
Seal lips around mouthpiece during inhalation 0 (0) 0 (0)
Synchronize actuation and inhalation 5 (25.0) 1 (5.0) 0.182
Inhale slowly and deeply 6 (30.0) 2 (10.0) 0.235

Data are presented as numbers (percentages).