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. 2020 Nov 12;10:19759. doi: 10.1038/s41598-020-75755-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PCA score plot. It shows groups of saliva samples based on 331 putative metabolites analyzed on a ZIC-pHILIC column. The data was Pareto scaled. (A) Green and light green are controls; pre-training for both day 1 and 2 respectively (n = 26 of each day), and blue and light blue are treated; post-training for both day 1 and 2 respectively (n = 26 of each day), (B) green is control; pre-training for both day 1 and 2 respectively (n = 52) and blue is treated; post-training for both day 1 and 2 respectively (n = 52).