Table 1.

Filtration processes using Microsoft Excel and SIMCA-P version 14.1.

Filtration	Plasma (C4) features	Plasma (HILIC) features	Urine (HILIC) features	Saliva (HILIC) features
Total number of features, data extracted using m/z Mine 2.14	838	887	9403	9402
Unknown features which were excluded	720	587	7346	7176
Identified Metabolites with RSD > 20 which were excluded	34	300	2057	1714
Metabolites with P value < 0.05 which were included	20	211	126	331
Biomarkers were only reported as significantly influencing the models	6	75	16	32