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. 2020 Nov 12;10:19653. doi: 10.1038/s41598-020-76759-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Scheme of GMStool. (A) Overall workflow. GMStool consists of three phases: preparation, marker selection, and final modeling. The dotted rectangles indicate the options that users can choose: whether to define pre-selected markers and which model to use for the marker selection and final modeling phases. (B) A brief algorithm for the marker selection phase. "preset marker” in the first conditional statement means the "pre-selected markers” in the overall workflow. Abbreviations ‘Set. corr.’ ‘Target corr.’, and ‘val. corr.’ mean ‘correlation rate of marker set’, ‘target correlation rate’, and ‘correlation rate of validation set’, respectively.