Table 3. Pair-to-pair analysis.
| A) MEC | |||
|---|---|---|---|
| Gene | log2 fc | p-value | signiling pathway |
| COMP | 22,82 | 0,00032522 | PI3K |
| WNT7B | 4,42 | 0,00000038 | Hedgehog, Wnt |
| COL1A1 | 30,76 | 0,00004253 | PI3K |
| BMP7 | 6,91 | 0,00000031 | TGF-beta |
| FZD10 | 6,9 | 0,0000024 | Wnt |
| COL11A1 | 16,69 | 0,00000789 | PI3K |
| CCR7 | 7,28 | 0,00044422 | Transcriptional Misregulation |
| SFRP2 | 11,79 | 0,00042547 | Wnt |
| COL1A2 | 12,99 | 0,00003073 | PI3K |
| SPP1 | 7,34 | 0,00082186 | PI3K |
| FN1 | 9,31 | 0,00015914 | PI3K |
| FGFR3 | 9,66 | 0,00000063 | Driver Gene, MAPK, PI3K, Ras |
| COL3A1 | 11,29 | 0,00015946 | PI3K |
| DUSP4 | 9,57 | 0,00000154 | MAPK |
| COL5A1 | 8,48 | 0,00006621 | PI3K |
| WNT5A | -2,24 | 0,12500988 | Wnt |
| TNR | -1,02 | 0,3388007 | PI3K |
| PRKAA2 | -3,79 | 0,00071002 | PI3K |
| PAK3 | -1,75 | 0,01448371 | Ras |
| RXRG | -1,32 | 0,1345256 | Transcriptional Misregulation |
| PLCB1 | -5,35 | 0,00000284 | Wnt |
| LIFR | -6,4 | 0,00000095 | JAK-STAT |
| COL6A6 | -1,07 | 0,74636859 | PI3K |
| CAMK2B | -1,89 | 0,01919538 | Wnt |
| PLCB4 | -7,97 | 0,00000867 | Wnt |
| WIF1 | -7,23 | 0,00811211 | Wnt |
| MAPT | -5,03 | 0,00023095 | MAPK |
| LRP2 | -3 | 0,00303356 | Hedgehog |
| EGF | -6,71 | 0,00051303 | MAPK, PI3K, Ras |
| CALML5 | -18,29 | 0,0000097 | Ras |
| B) ACC | |||
| Gene | log2 fc | p-value | signiling pathway |
| COMP | 11,85 | 0,00005072 | PI3K |
| TLX1 | 9,68 | 0,00027461 | Transcriptional Misregulation |
| MYB | 14,63 | 0,00005751 | PI3K |
| BMP7 | 12,37 | 0,00001101 | TGF-beta |
| AMH | 4,73 | 0,0000381 | TGF-beta |
| STMN1 | 13,26 | 0,00000004 | MAPK |
| BRIP1 | 7,13 | 0,00000001 | DNA Damage – Repair |
| ETV4 | 6,45 | 0,00000302 | Transcriptional Misregulation |
| COL27A1 | 9,98 | 0,00000016 | PI3K |
| HIST1H3B | 8,99 | 0,00000451 | Driver Gene, Transcriptional Misregulation |
| BMPR1B | 8,81 | 0,00015217 | TGF-beta |
| FANCA | 5,1 | 0,00000001 | DNA Damage - Repair |
| BMP8A | 2,64 | 0,00296188 | TGF-beta |
| RASGRP1 | 4,31 | 0,00101834 | MAPK, Ras |
| RAD51 | 1,39 | 0,00652304 | DNA Damage - Repair |
| ANGPT1 | −6,72 | 0,00000003 | PI3K, Ras |
| FUT8 | −8,03 | 0,00000001 | Transcriptional Misregulation |
| CHAD | −6,3 | 0,00006851 | PI3K |
| FGF10 | −5,6 | 0,00000005 | MAPK, PI3K, Ras |
| FGF22 | −2,82 | 0,00007386 | MAPK, PI3K, Ras |
| LEP | −2,08 | 0,00080883 | JAK-STAT |
| ACVR1C | −1,78 | 0,00235731 | TGF-beta |
| IL19 | −1,71 | 0,00470287 | JAK-STAT |
| SIX1 | −8,42 | 0,00000773 | Transcriptional Misregulation |
| WNT5A | −13,69 | 0,00000014 | Hedgehog, Wnt |
| FGF12 | −9,87 | 0,00000001 | MAPK, PI3K, Ras |
| EGF | −12,82 | 0,00000001 | MAPK, PI3K, Ras |
| WIF1 | −17,79 | 0,00053199 | Wnt |
| ETV1 | −31,74 | 0,00000001 | Transcriptional Misregulation |
| LRP2 | −9,36 | 0,00000001 | Hedgehog |
| C) AC-NOS | |||
| Gene | log2 fc | p-value | signiling pathway |
| COMP | 16,8 | 0,00000001 | PI3K |
| SPP1 | 10,39 | 0,00000001 | PI3K |
| COL1A1 | 7,02 | 0,00000001 | PI3K |
| WNT7B | 3,26 | 0,00000001 | Hedgehog, Wnt |
| MMP9 | 4,48 | 0,00007157 | Transcriptional Misregulation |
| FN1 | 7,85 | 0,00000001 | PI3K |
| ZIC2 | 1,66 | 0,00045604 | Hedgehog |
| HIST1H3B | 6,5 | 0,00000001 | Driver Gene, Transcriptional Misregulation |
| IBSP | 1,61 | 0,00140148 | PI3K |
| UBE2T | 4,63 | 0,00000001 | DNA Damage - Repair |
| WNT2 | 1,7 | 0,00000115 | Wnt |
| ITGB6 | 6,13 | 0,00000001 | PI3K |
| HIST1H3G | 4,92 | 0,00000001 | Driver Gene, Transcriptional Misregulation |
| FGFR4 | 2,02 | 0,0000605 | MAPK, PI3K, Ras |
| COL1A2 | 6,07 | 0,00000001 | PI3K |
| COL6A6 | −1,25 | 0,04340979 | PI3K |
| CACNB2 | −4,42 | 0,00000001 | MAPK |
| RXRG | −1,37 | 0,00009869 | Transcriptional Misregulation |
| PROM1 | −3,11 | 0,000004 | Transcriptional Misregulation |
| LRP2 | −4 | 0,00000001 | Hedgehog |
| IL19 | −1,41 | 0,00010192 | JAK-STAT |
| PLCB4 | −7,6 | 0,00000001 | Wnt |
| ETV1 | −11,53 | 0,00000001 | Transcriptional Misregulation |
| EGF | −9,14 | 0,00000001 | MAPK, PI3K, Ras |
| PPARGC1A | −4,53 | 0,00000001 | Chromatin Modification |
| FGF22 | −2,17 | 0,00000001 | MAPK, PI3K, Ras |
| CALML3 | −1,45 | 0,02524279 | Ras |
| CHAD | −3,19 | 0,00001052 | PI3K |
| RASAL1 | −5,81 | 0,00000001 | Ras |
| WIF1 | −12,16 | 0,00000001 | Wnt |