Table 1.
Sensitivity of Target Detection in Samples with MRD Detectable by One Method Only.
| Patient ID | AML Subtype | Sample Type | Days Post DG | MRD FT | FT Detection Sensitivity | MRD FG | FG Detection Sensitivity |
|---|---|---|---|---|---|---|---|
| M531 | PML-RARA | BM | 27 | NEG | 2,96E−03 | 1,22E−02 | 1,00E−04 |
| M627 | PML-RARA | BM | 56 | NEG | 6,94E−02 | 3,62E−03 | 1,00E−05 |
| M620 | CBFB-MYH11 | PB | 104 | NEG | 9,17E−04 | 1,76E−03 | 1,00E−05 |
| M623 | RUNX1-RUNX1T1 | BM | 168 | NEG | 6,49E−05 | 1,53E−03 | 1,00E−05 |
| M567 | CBFB-MYH11 | PB | 57 | NEG | 9,81E−04 | 5,20E−04 | 1,00E−05 |
| M590 | PML-RARA | PB | 26 | NEG | 1,31E−03 | 3,70E−04 | 1,00E−05 |
| M627 | PML-RARA | PB | 80 | NEG | 9,55E−04 | 3,20E−04 | 1,00E−05 |
| M637 | CBFB-MYH11 | BM | 208 | NEG | 1,63E−04 | 3,00E−04 | 1,00E−05 |
| M615 | PML-RARA | PB | 54 | NEG | 2,34E−02 | 2,60E−04 | 1,00E−05 |
| M606 | CBFB-MYH11 | PB | 28 | NEG | 6,95E−04 | 2,40E−04 | 1,00E−05 |
| M617 | PML-RARA | BM | 85 | NEG | 1,08E−01 | 9,00E−05 | 1,00E−05 |
| M567 | CBFB-MYH11 | PB | 26 | NEG | 6,18E−04 | NQP | 1,00E−05 |
| M592 | CBFB-MYH11 | PB | 90 | NEG | 3,22E−04 | NQP | 1,00E−05 |
| M599 | RUNX1-RUNX1T1 | PB | 59 | NEG | 4,93E−05 | NQP | 1,00E−05 |
| M606 | CBFB-MYH11 | BM | 61 | NEG | 8,43E−04 | NQP | 1,00E−04 |
| M606 | CBFB-MYH11 | BM | 103 | NEG | 3,66E−04 | NQP | 1,00E−04 |
| M612 | PML-RARA | BM | 55 | NEG | 2,45E−03 | NQP | 1,00E−04 |
| M612 | PML-RARA | PB | 55 | NEG | 4,45E−03 | NQP | 1,00E−04 |
| M612 | PML-RARA | BM | 81 | NEG | 5,28E−04 | NQP | 1,00E−04 |
| M615 | PML-RARA | BM | 81 | NEG | 8,09E−03 | NQP | 1,00E−05 |
| M623 | RUNX1-RUNX1T1 | PB | 168 | NEG | 1,26E−04 | NQP | 1,00E−05 |
| M623 | RUNX1-RUNX1T1 | PB | 381 | NEG | 1,76E−05 | NQP | 1,00E−05 |
| M627 | PML-RARA | BM | 80 | NEG | 1,71E−03 | NQP | 1,00E−05 |
| M627 | PML-RARA | BM | 112 | NEG | 2,72E−04 | NQP | 1,00E−05 |
| M608 | RUNX1-RUNX1T1 | BM | 207 | 4,68E-04 | 4,58E−04 | NEG | 1,00E−04 |
| M531 | PML-RARA | BM | 254 | NQP | 1,77E−04 | NEG | 1,00E−04 |
| M569 | RUNX1-RUNX1T1 | PB | 574 | NQP | 2,14E−05 | NEG | 1,00E−05 |
| M599 | RUNX1-RUNX1T1 | BM | 101 | NQP | 1,01E−05 | NEG | 1,00E−05 |
| M599 | RUNX1-RUNX1T1 | BM | 143 | NQP | 1,24E−04 | NEG | 1,00E−05 |
In samples with MRD negative by FT-based approach, but quantifiably positive by FG-approach at the levels above the sensitivity of FT-detection, the FT-detection sensitivity is highlighted in blue. Red color highlights the sensitivities of FG detection deeper compared to those of FT detection in samples with MRD negative by FG- but positive by FT-based approach.
BM = bone marrow, DG = diagnosis, FG = fusion gene, FT = fusion transcript, MRD = minimal residual disease, PB = peripheral blood.