TABLE 2.
Comparison of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients With and Without Invasive Pulmonary Aspergillosis
| Variables | IPA (n = 6) | Non-IPA (n = 40) | p |
|---|---|---|---|
| Demographic characteristics | |||
| Age (yr) | 68 (60.7–71.5) | 66 (55.5–70) | 0.5 |
| Gender male, n (%) | 6 (100) | 29 (72.5) | 0.31 |
| Comorbidities | |||
| Obesity (body mass index > 30 kg/m2), n (%) | 3 (50) | 30 (75) | 0.33 |
| Diabetes, n (%) | 2 (33.3) | 17 (42.5) | 1 |
| Chronic obstructive pulmonary disease, n (%) | 3 (7.5) | 3 (50) | 0.022 |
| Cancer, n (%) | 0 (0) | 6 (15) | 0.59 |
| Immunosuppression except steroids, n (%) | 2 (33.3) | 3 (7.5) | 0.12 |
| Frailty score | 3 (3–4.2) | 2 (2–3) | 0.039 |
| Charlson comorbidity index | 2 (2–2.7) | 1 (1–2) | 0.07 |
| Severity scores at ICU admission | |||
| Sepsis-Related Organ Failure Assessment score | 10.5 (6.2–12.2) | 5.5 (4–7) | 0.047 |
| Simplified Acute Physiology Score II | 67.5 (60–74) | 38 (28–58.7) | 0.002 |
| Laboratory data at ICU admission | |||
| Albumin (g/L) | 19.5 (17–22.7) | 26.5 (23–31.7) | 0.001 |
| C-reactive protein (mg/L) | 289.5 (143.7–374) | 171 (115–230.7) | 0.064 |
| Leukocytes (G/L) | 9.3 (7.1–18.1) | 8.6 (5.9–10.9) | 0.25 |
| Creatinine (µmol/L) | 85.5 (50–141) | 70 (56.2–100) | 0.81 |
| Pao2/Fio2 (mm Hg) | 76.9 (1.1–150.4) | 114.1 (97.4–143.5) | 0.18 |
| Outcome | |||
| ICU death, n (%) | 4 (66.7) | 10 (25) | 0.06 |
| Hospital discharge before 60 d, n (%) | 0 (0) | 30 (75) | 0.001 |
| Systemic corticosteroids use, n (%) | 5 (83.3) | 4 (10) | 0.001 |
IPA = invasive pulmonary aspergillosis.
Boldface entries represent either the subparts (e.g., “Demographic characteristics”, “Comorbidities”) or highlight the significant p values (p < 0.05).