Table 2.
Laboratory Findings of the Study Cohorts. Results are Presented as Median (With Interquartile Range).
| Normal range | Cohort A (n = 204) | Cohort B (n = 81) | p value∗ | Cohort C (n = 23) | p value† | |
|---|---|---|---|---|---|---|
| Hemoglobin, g/dL | 13–17 | 14 (13.2–14.9) | 13.3 (11.9–14.7) | 0.003 | 14.3 (13.3–15.4) | n.s. |
| White blood cell count, ×109 per L | 4–10 | 5.8 (4.6–7.3) | 6.4 (4.6–9.0) | 0.033 | 5.3 (3.4–7.3) | n.s. |
| Lymphocyte count, ×109 per L | 1.0–4.8 | 1.5 (1.1–1.9) | 0.8 (0.6–1.1) | <0.001 | 1.0 (0.7–1.4) | <0.001 |
| CRP, mg/L | <5 | 13.2 (2.0–40.8) | 89.3 (37.6–148.1) | <0.001 | 46.4 (21.8–106.8) | <0.001 |
| Pprocalcitonin, ng/mL | < 0.05 | 0.05 (0.05–0.06) | 0.10 (0.06–0.30) | <0.001 | 0.06 (0.05–0.11) | <0.001 |
| Interleukin-6, pg/mL | <15 | n.a | 43.1 (15.8–83.8) | n.a. | ||
| Ferritin, μg/L | 30–300 | 227 (83–569) | 777 (341–1339) | <0.001 | 741 (404–935) | <0.001 |
| Iron, μmol/L | 14–32 | 8.6 (5.0–14.9) | 2.6 (1.8–3.9) | <0.001 | 3.2 (2.4–4.6) | <0.001 |
| Transferrin, g/L | 2.0–3.6 | 1.9 (1.6–2.3) | 1.5 (1.2–1.7) | <0.001 | 1.7 (1.6–1.9) | 0.012 |
| TfSat, % | 16–45 | 19 (12–28) | 7 (5–11) | <0.001 | 8 (6–10) | <0.001 |
| Hepcidin, ng/mL | 91.4 (59.6–133.7) | |||||
| LDH, U/L | <317 | 286 (232–360) | 384 (308–508) | <0.001 | 348 (272–374) | 0.005 |
| AST, U/L | <37 | n.a. | 42 (32–77) | n.a. | ||
| ALT, U/L | <35 | n.a. | 36 (27–57) | n.a. | ||
| Creatinine, mg/dL | 0.6–1.2 | 0.74 (0.65–0.88) | 0.88 (0.69–1.04) | <0.001 | 0.92 (0.79 – 1.11) | <0.001 |
| BUN, mg/dL | <45 | 25 (20–31) | 28 (21–44) | 0.001 | 29 (24 – 34) | 0.005 |
| NT-pro-BNP, ng/L | <125 | 99 (54–185) | 247 (109–849) | <0.001 | 85 (46–154) | n.s. |
| Troponin-T, pg/mL | <14 | na | 11.5 (6.0–22.3) | n.a. |
Laboratory values in cohort B were obtained at day of admission. Laboratory values in cohort A and C were obtained during outpatient visits. Cohort A and C: All available values were included in analysis. Cohort B: only values of the day of admission were included in the analysis.
AST = alanine aminotransferase, AST = aspartate aminotransferase, BUN = blood urea nitrogen, CRP = C-reactive protein, LDH = lactate dehydrogenase, n.a. = not analyzed, PCT = procalcitonin, TfSat = transferrin saturation.
∗
Comparison of p values between cohort A and B.
†
Comparison of p values between cohort A and C.