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. 2020 Nov 10;6(12):e624. doi: 10.1097/TXD.0000000000001077

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Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 6. — Effects of quercetin and sucrose on the EGTI histology score in kidney tissue. Renal tissues were stained with hematoxylin-eosin (H&E), and pathological changes were evaluated using the EGTI scoring system under a light microscope at 400× magnification. A, H&E stain in G1 shows a glomerular tuft retraction (Glomerular score 2: ▾), complete necrosis in tubular cells (Tubular score 4: →), and inflammation and necrosis within the interstitium (Interstitial score 3: *). B, H&E stain in G2 shows a thickened Bowman’s capsule (Glomerular score 1: ▾) and thickened basal membrane of the tubular cells with loss of the brush border and the presence of cast formation (Tubular score 3: →). C, H&E stain in G3 shows the integrity of the basal membrane of the tubular cells with loss of the brush border in less than 25% of the tubular cells (Tubular score 1: →) and an intact glomerulus with thin-walled Bowman’s capsule (Glomerular score 0: ▾). There is no visible interstitium, signifying no damage/abnormality within the interstitial compartment (Interstitial score 0: *). In (D), the scoring graph shows data as the mean ± SD (G1: n = 2, G2: n = 4, G3: n = 4). Differences between each group were calculated using the Student’s t-test. G1:CS × 24h, G2:CS × 22h + HOPE × 2h, G3:supCS × 22h + supHOPE × 2h. CS, cold storage; EGTI, endothelial, glomerular, tubular, interstitial; HOPE, hypothermic oxygenated perfusion.