Table 3.

Distribution of HI classification on the basis of biological sex

HI categorya	Women				Men (n = 173)		Overall (n = 306)
	Premenopausal (n = 73)		Postmenopausal (n = 60)
	Baseline	End of follow-up	Baseline	End of follow-up	Baseline	End of follow-up	Baseline	End of follow-up
HI 4	1	3	7	11	27	42	35	56
Liver disease
Hepatocellular carcinomab					1	1	1	1
Cirrhosis		1	2	3	3	5	5	9
Fibrosis ± iron depositsc			1	2	6	6	7	8
Iron deposits with AST > 45 IU/L, or ALT > 40 IU/L	1	1			3	3	4	4
AST > 45 IU/L, or ALT > 40 IU/L		1	4	6	14	26	18	33
Metacarpophalangeal arthritis						1		1
HI 3	4	2	6	9	38	38	48	49
HI 2	28	34	30	31	67	69	123	134
HI 1	40	34	17	9	41	24	100	67
Total	73	73	60	60	173	173	306	306

Information on diabetes was not collected.

ALT, alanine aminotransferase; AST, aspartate aminotransferase; HCC, hepatocellular carcinoma; HI, Health Iron.

^aPlease refer to HI classification table on Table 2.

^bSubjects listed as HCC also had cirrhosis.

^cSubjects with both fibrosis and iron deposits on biopsy was categorized as having fibrosis.