Table 5.
Sensitivity of Assaysa
| DiaSorin | EUROIMMUN, Indeterminate = Positive | EUROIMMUN, Indeterminate = Negative | Roche | Siemens | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sample Group | Positive/ Samples, No. | Sensitivity (95% CI) | Positive/ Samples, No. | Sensitivity (95% CI) | Positive/ Samples, No. | Sensitivity (95% CI) | Positive/ Samples, No. | Sensitivity (95% CI) | Positive/ Samples, No. | Sensitivity (95% CI) |
| All RT-PCR+ | 87/124 | 70.2 (61.3-78.0) | 104/131 | 79.4 (71.5-86.0) | 97/131 | 74.1 (65.7-81.3) | 109/129 | 84.5 (77.1-90.3) | 103/131 | 78.6 (70.6-85.3) |
| All RT-PCR+ symptoms ≥10 d | 83/114 | 72.8 (63.7-80.7) | 98/121 | 81.0 (72.9-87.6) | 92/121 | 76.0 (67.4-83.3) | 103/119 | 86.6 (79.1-92.1) | 97/121 | 80.2 (71.9-86.9) |
| All RT-PCR+ symptoms ≥12 d | 75/98 | 76.5 (66.9-84.5) | 88/104 | 84.6 (76.2-90.9) | 82/104 | 78.9 (69.7-86.2) | 92/103 | 89.3 (81.7-94.6) | 87/104 | 83.7 (75.1-90.2) |
| All RT-PCR+ symptoms ≥14 d | 68/82 | 82.9 (73.0-90.3) | 79/84 | 94.1 (86.7-98.0) | 74/84 | 88.1 (79.2-94.1) | 81/83 | 97.6 (91.6-99.7) | 78/84 | 92.9 (85.1-98.7) |
| All RT-PCR+ symptoms ≥16 d | 56/65 | 86.2 (75.3-93.5) | 63/65 | 96.9 (89.3-99.6) | 60/65 | 92.3 (83.0-97.5) | 64/65 | 98.5 (91.7->99.5) | 62/65 | 95.4 (87.1-99.0) |
| All RT-PCR+ symptoms ≥18 d | 44/50 | 88.0 (75.7-95.5) | 48/50 | 96.0 (86.3-99.5) | 46/50 | 92.0 (80.8-97.8) | 50/50 | 100 (92.9-100) | 49/50 | 98.0 (89.4->99.9) |
| Unique patients | 56/65 | 86.2 (75.3-93.5) | 64/68 | 94.1 (85.6-98.4) | 62/68 | 91.2 (81.8-96.7) | 63/67 | 94.0 (85.4-98.4) | 63/68 | 92.7 (83.7-97.6) |
| Unique patients’ symptoms ≥14 d on last sample | 50/57 | 87.7 (76.3-94.9) | 56/58 | 96.6 (88.1-99.6) | 54/58 | 93.1 (83.3-98.1) | 57/58 | 98.3 (90.8->99.9) | 56/58 | 96.6 (88.1-99.6) |
CI, confidence interval; RT-PCR, reverse transcription polymerase chain reaction.
aSensitivities of each assay are determined at varying thresholds for number of days after onset of symptoms. For EUROIMMUN, calculations are provided for categorizing indeterminate results as positive or negative.