Table 6.
Estimated Positive Predictive Values at Varying Frequencies of COVID-19 Prevalencea
| DiaSorin PPV (95% CI), % | EUROIMMUN PPV (95% CI), Indeterminate = Positive, % | EUROIMMUN PPV (95% CI), Indeterminate = Negative, % | Roche PPV (95% CI), % | Siemens PPV (95% CI), % | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Prevalence | All Samples | ≥14 Days After Symptom Onset | All Samples | ≥14 Days After Symptom Onset | All Samples | ≥14 Days After Symptom Onset | All Samples | ≥14 Days After Symptom Onset | All Samples | ≥14 Days After Symptom Onset |
| 1 | 17.9 (10.1-40.6) | 20.5 (11.8-44.6) | 8.6 (5.8-14.1) | 10.4 (6.8-16.2) | 16.7 (9.8-36.2) | 19.3 (11.3-37.9) | 100 (36.2-100) | 100 (39.9-100) | 100 (34.6-100) | 100 (38.2-100) |
| 5 | 53.2 (37.0-78.0) | 57.4 (41.1-80.7) | 32.9 (24.2-46.1) | 36.8 (27.5-50.1) | 51.1 (36.2-74.7) | 55.5 (39.8-76.1) | 100 (74.7-100) | 100 (77.6-100) | 100 (73.4-100) | 100 (76.3-100) |
| 10 | 70.6 (55.4-88.2) | 74.0 (59.6-89.8) | 50.9 (40.2-64.3) | 55.1 (44.5-68.0) | 68.8 (54.5-86.2) | 72.4 (58.3-87.0) | 100 (86.2-100) | 100 (88.0-100) | 100 (85.3-100) | 100 (87.2-100) |
| 20 | 84.4 (73.6-94.4) | 86.5 (76.8-95.2) | 70.0 (60.2-80.2) | 73.4 (64.3-82.7) | 83.3 (73.0-93.4) | 85.5 (75.9-93.8) | 100 (93.4-100) | 100 (94.3-100) | 100 (92.9-100) | 100 (93.9-100) |
CI, confidence interval; PPV, positive predictive value.
aPPVs are shown as the point estimate (%) and 95% confidence interval based on bootstrapped likelihood ratios.