Table 2.
Association between risk factors and mortality in hospitalised patients with COVID-19
| Time-to-death within 30 days | Time-to-death within 60 days | |||||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | Hazard ratio (95% CI) | |||||
| N died/N total (%) | Crude | Adjusted | N died/N total (%) | Crude | Adjusted | |
| Age | ||||||
| 50–64 years old | 172/646 (27) | (reference) | (reference) | 212/646 (33) | (reference) | (reference) |
| 65–79 years old | 244/587 (42) | 1.7 (1.4–2.1) | 1.5 (1.2–1.8) | 276/587 (47) | 1.6 (1.4–1.9) | 1.4 (1.2–1.7) |
| ≥ 80 years old | 110/195 (56) | 2.8 (2.2–3.6) | 2.3 (1.8–3.0) | 117/195 (60) | 2.5 (2.0–3.2) | 2.1 (1.7–2.6) |
| Sex | ||||||
| Female | 204/603 (34) | (reference) | (reference) | 234/603 (39) | (reference) | (reference) |
| Male | 322/825 (39) | 1.2 (1.0–1.4) | 1.3 (1.1–1.6) | 371/825 (45) | 1.2 (1.0–1.4) | 1.4 (1.1–1.6) |
| Charlson score | ||||||
| 0 points | 101/379 (27) | (reference) | (reference) | 124/379 (33) | (reference) | (reference) |
| 1 point | 111/340 (33) | 1.3 (1.0–1.7) | 1.2 (0.9–1.6) | 123/340 (36) | 1.2 (0.9–1.5) | 1.1 (0.9–1.4) |
| 2–3 points | 129/340 (38) | 1.6 (1.3–2.1) | 1.5 (1.2–2.0) | 151/340 (45) | 1.6 (1.2–2.0) | 1.5 (1.2–1.9) |
| ≥ 4 points | 185/369 (50) | 2.4 (1.8–3.0) | 2.3 (1.7–2.9) | 207/369 (56) | 2.2 (1.8–2.7) | 2.2 (1.7–2.7) |
| NEWS | ||||||
| 0–5 points | 66/387 (17) | (reference) | (reference) | 81/387 (21) | (reference) | (reference) |
| 6–7 points | 98/340 (29) | 1.9 (1.4–2.5) | 1.9 (1.4–2.6) | 120/340 (35) | 1.9 (1.4–2.5) | 1.9 (1.4–2.5) |
| 8–9 points | 140/331 (42) | 3.0 (2.2–4.0) | 3.3 (2.5–4.4) | 161/331 (49) | 2.9 (2.2–3.8) | 3.2 (2.4–4.2) |
| ≥ 10 points | 222/370 (60) | 4.8 (3.6–6.3) | 4.1 (3.1–5.5) | 243/370 (66) | 4.6 (3.5–5.9) | 4.0 (3.1–5.2) |
| PRO-AGEa | ||||||
| 0–1 point | 54/328 (16) | (reference) | (reference) | 71/328 (22) | (reference) | (reference) |
| 2–3 points | 146/500 (29) | 1.9 (1.4–2.6) | 1.6 (1.1–2.1) | 170/500 (34) | 1.7 (1.3–2.3) | 1.4 (1.1–1.9) |
| 4 points | 139/301 (46) | 3.4 (2.5–4.6) | 2.1 (1.5–3.0) | 159/301 (53) | 3.1 (2.3–4.1) | 2.0 (1.5–2.7) |
| 5–7 points | 187/299 (63) | 5.4 (4.0–7.3) | 3.0 (2.2–4.1) | 205/299 (69) | 4.8 (3.6–6.3) | 2.8 (2.1–3.8) |
aWe used a modified version of the PRO-AGE score, excluding ‘older age (≥90 years old)’ from the algorithm.
Estimates were calculated using Cox proportional hazards models. Quartiles defined the categories of Charlson, NEWS and modified PRO-AGE scores. CI, confidence interval.