Table 3.
Mortality in patients hospitalised with COVID-19 according to levels of NEWS (illness acuity) and modified PRO-AGE score (vulnerability)
| NEWS | PRO-AGE scoresa | Time-to-death within 60 days | ||||
|---|---|---|---|---|---|
| N died/N total (%) | Hazard ratio (95% CI) | ||||
| Crude model | P-valueb | Adjusted model | P-valueb | ||
| NEWS 0–5 | PRO-AGE 0–3 | 47/284 (17) | (reference) | (reference) | ||
| NEWS 0–5 | PRO-AGE 4–7 | 34/103 (33) | 2.3 (1.5–3.5) | <0.001 | 1.9 (1.2–2.9) | 0.005 |
| NEWS 6–7 | PRO-AGE 0–3 | 65/237 (27) | 1.8 (1.3–2.7) | 1.9 (1.3–2.7) | ||
| NEWS 6–7 | PRO-AGE 4–7 | 55/103 (53) | 4.1 (2.8–6.1) | <0.001 | 3.6 (2.4–5.3) | <0.001 |
| NEWS 8–9 | PRO-AGE 0–3 | 77/198 (39) | 2.7 (1.9–3.9) | 3.2 (2.2–4.6) | ||
| NEWS 8–9 | PRO-AGE 4–7 | 84/133 (63) | 5.7 (4.0–8.2) | <0.001 | 5.8 (4.0–8.3) | <0.001 |
| NEWS ≥ 10 | PRO-AGE 0–3 | 52/109 (48) | 3.7 (2.5–5.4) | 4.1 (2.7–6.1) | ||
| NEWS ≥10 | PRO-AGE 4–7 | 191/261 (73) | 7.2 (5.2–10.0) | <0.001 | 7.3 (5.3–10.1) | <0.001 |
Estimates were calculated using Cox proportional hazards models. The adjusted model included age, sex and Charlson comorbidity score. CI, confidence interval.
aWe used a modified version of the PRO-AGE score, excluding ‘older age (≥90 years old)’ from the algorithm. Quartiles defined the categories of NEWS and modified PRO-AGE scores; for the modified PRO-AGE score, we combined the two lower and two higher quartiles, resulting in two levels of vulnerability.
bPairwise comparisons between modified PRO-AGE scores: 0–3 versus 4–7 within the same stratum of NEWS.