Table 2.
Top pathways from KEGG, WikiPathways, Reactome and BioCarta databases and their corresponding P-values and genes for common differentially expressed genes
| Databases | Pathways | P-value | Genes |
|---|---|---|---|
| KEGG | IL-17 signaling pathway | 0.00001563 | MMP9, S100A9, S100A8 |
| TNF signaling pathway | 0.001596 | MMP9, ICAM1 | |
| Leukocyte transendothelial migration | 0.001654 | MMP9, ICAM1 | |
| African trypanosomiasis | 0.02017 | ICAM1 | |
| Bladder cancer | 0.02233 | MMP9 | |
| Fluid shear stress and atherosclerosis | 0.002531 | MMP9, ICAM1 | |
| Malaria | 0.02663 | ICAM1 | |
| Viral myocarditis | 0.03198 | ICAM1 | |
| Staphylococcus aureus infection | 0.03678 | ICAM1 | |
| Peroxisome | 0.04473 | SOD2 | |
| WikiPathways | Vitamin B12 Metabolism WP1533 | 3.630e-11 | SERPINA3, SAA1, SAA2, SOD2, ICAM1 |
| IL1 and megakaryocytes in obesity WP2865 | 2.489e-7 | MMP9, S100A9, ICAM1 | |
| Folate Metabolism WP176 | 1.525e-10 | SERPINA3, SAA1, SAA2, SOD2, ICAM1 | |
| Selenium Micronutrient Network WP15 | 5.914e-10 | SERPINA3, SAA1, SAA2, SOD2, ICAM1 | |
| Mammary gland development pathway - Involution (Stage 4 of 4) WP2815 | 0.005488 | MMP9 | |
| Photodynamic therapy-induced NF-kB survival signaling WP3617 | 0.0001620 | MMP9, ICAM1 | |
| Osteopontin Signaling WP1434 | 0.007129 | MMP9 | |
| Platelet-mediated interactions with vascular and circulating cells WP4462 | 0.009313 | ICAM1 | |
| Cells and Molecules involved in local acute inflammatory response WP4493 | 0.009313 | ICAM1 | |
| Extracellular vesicles in the crosstalk of cardiac cells WP4300 | 0.01040 | MMP9 | |
| Reactome | DEx/H-box helicases activate type I IFN and inflammatory cytokines production Homo sapiens R-HSA-3134963 | 0.00002138 | SAA1, S100A12 |
| Advanced glycosylation endproduct receptor signaling Homo sapiens R-HSA-879415 | 0.00002138 | SAA1, S100A12 | |
| Scavenging by Class B Receptors Homo sapiens R-HSA-3000471 | 0.002747 | SAA1 | |
| RIP-mediated NFkB activation via ZBP1 Homo sapiens R-HSA-1810476 | 0.00005742 | SAA1, S100A12 | |
| TRAF6 mediated NF-kB activation Homo sapiens R-HSA-933542 | 0.00007540 | SAA1, S100A12 | |
| ZBP1(DAI) mediated induction of type I IFNs Homo sapiens R-HSA-1606322 | 0.00008873 | SAA1, S100A12 | |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens R-HSA-445989 | 0.00008873 | SAA1, S100A12 | |
| Formyl peptide receptors bind formyl peptides and many other ligands Homo sapiens R-HSA-444473 | 0.004392 | SAA1 | |
| Cytosolic sensors of pathogen-associated DNA Homo sapiens R-HSA-1834949 | 0.0005787 | SAA1, S100A12 | |
| TRAF6 Mediated Induction of proinflammatory cytokines Homo sapiens R-HSA-168180 | 0.0006883 | SAA1, S100A12 | |
| BioCarta | Inhibition of Matrix Metalloproteinases Homo sapiens h reckPathway | 0.004392 | MMP9 |
| Cardiac Protection Against ROS Homo sapiens h flumazenilPathway | 0.006035 | SOD2 | |
| Erythropoietin mediated neuroprotection through NF-kB Homo sapiens h eponfkbPathway | 0.007129 | SOD2 | |
| The IGF-1 Receptor and Longevity Homo sapiens h longevity pathway | 0.008767 | SOD2 |