Table 3.
Analysis of prognostic factors associated with either ICU admission or death
| Adverse prognostic factors | Univariate |
Multivariate |
||
|---|---|---|---|---|
| OR (95% CI) | P a | OR (95% CI) | P a | |
| Patient-related parameters | ||||
| Age, >70 y (vs ≤70) | 2.44 (1.06 to 5.53) | .04 | 2.36 (0.55 to 9.65) | .21 |
| WHO performance status, ≥2 (vs 0-1) | 3.64 (1.18 to 10.12) | <.01 | — | |
| BMI, ≥30 kg/m2 (vs <30) | 0.57 (0.16 to 2.08) | .25 | — | |
| Male (vs female) | 2.57 (1.09 to 5.80) | .02 | — | |
| Any comorbidity, Yes (vs No) | 1.20 (0.48 to 2.66) | .64 | — | |
| Hypertension, Yes (vs No) | 1.88 (0.91 to 4.29) | .10 | — | |
| Smoking, Yes (vs No) | 0.85 (0.25 to 2.56) | .92 | — | |
| Concomitant medications, Yes (vs No) | ||||
| Corticosteroids | 1.45 (0.62 to 3.73) | .43 | ||
| NSAID | 0.42 (0.09 to 3.53) | .42 | — | |
| ACE inhibitor/ARB | 1.49 (0.61 to 3.72) | .48 | — | |
| Anticoagulants | 1.99 (0.87 to 4.59) | .11 | — | |
| Immunosuppressants | 3.20 (0.60 to 17.10) | .16 | —— | |
| Inpatients infection (vs outpatient) | 1.11 (0.54 to 2.75) | .80 | — | |
| Cancer-related parameters | ||||
| Site | ||||
| Breast | 1 (Referent) | 1 (Referent) | ||
|
Nonbreast Lung Other solid tumor Hematological malignancy |
3.64 (1.44 to 8.88) 3.55 (1.11 to 12.60) 4.51 (1.29 to 15.63) 3.26 (1.17 to 8.16) |
<.01 |
3.55 (0.76 to 17.10) — — — |
.12 |
| Cancer stage (solid tumors) | ||||
| Advanced/metastatic (vs localized) | 3.15 (1.00 to 10.25) | .05 | — | |
| Pleuropulmonary metastasis (solid tumors) | ||||
| Yes (vs No) |
1.04 (0.35 to 2.84) |
.98 |
— |
|
| Therapeutic intent | ||||
| Curative | 1 (Referent) | — | ||
| Control | 1.75 (0.66 to 4.89) | .01b | — | |
| Palliative | 4.65 (1.73 to 12.74) | — | ||
| Line of treatment | ||||
| Neoadjuvant/Adjuvant (referent) | 1 (Referent) | — | ||
| Metastatic, ≤2 lines | 2.11 (0.48 to 9.45) | .02b | — | |
| Metastatic, ≥3 lines | 4.51 (1.42 to 14.31) | — | ||
| COVID-19–related parameters | ||||
| Symptoms | ||||
| Dyspnea, Yes (vs No) | 4.34 (1.93 to 9.63) | <.01 | — | |
| Fever, Yes (vs No) | 1.72 (0.81 to 3.73) | .19 | — | |
| SpO2 <96%, Yes (vs No) | 3.64 (1.34 to 10.67) | .02 | 6.71 (1.40 to 30.10) | .01 |
| Radiology | ||||
| % alteration (per category) | 2.39 (1.27 to 4.18) | .003 | 2.48 (1.29 to 4.79) | .004 |
a
Wald statistics. All tests are 2-sided. ACE = angiotensin-converting enzyme; ARB = angiotensin II receptor blocker; BMI = body mass index; CI = confidence interval; ICU = intensive care unit; NSAID = nonsteroidal anti-inflammatory drugs; OR = odds ratio; SpO2 = oxygen saturation as detected by the pulse oximeter; WHO = World Health Organization.
b
Global P values are presented.