Table 2.

Logistic Regression Analyses in Terms of Risk for ICU Admission During Hospital Stay and Need for Mechanical Ventilation^a

	Logistic Regression Analysis
	Risk for ICU Admission						Need for Mechanical Ventilation
	Univariate Model			Multivariate Model			Univariate Model			Multivariate Model
	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
Demographic characteristics
Age, y	1.043	1.001–1.088	.047	0.938	0.858–1.026	.164	1.049	1.000–1.101	.051
Women vs men	0.224	0.060–0.847	.027	0.118	0.008–1.829	.126	0.216	0.045–1.028	.054
Clinical characteristics
SpO2, %	0.847	0.754–0.952	.005	0.969	0.788–1.192	.768	0.829	0.731–0.941	.004	0.977	0.818–1.167	.795
O2 requirement, Lb	1.538	1.185–1.997	.001	1.457	0.854–2.484	.167	1.736	1.257–2.399	.001	1.434	0.874 -2.352	.154
Laboratory parameters
eGFR, mL/min	0.975	0.951–0.999	.043				0.977	0.952–1.003	.081
Leukocytes, G/L	1.535	1.218–1.936	<.001				1.348	1.114–1.631	.002
Lymph absolute, G/Lb	0.234	0.078–0.708	.010				0.249	0.081–0.765	.015
CRP, mg/dLb	3.245	1.816–5.796	<.001				5.360	2.266–12.679	<.001
IL-6, ng/Lb	4.621	2.154–9.914	<.001				4.724	2.155–10.356	<.001
PCT, ng/mLb	1.412	0.936–2.129	.100				1.400	0.892–2.199	.144
Neopterin, nmol/Lb	9.243	2.553–33.468	.001				16.456	3.215–84.222	.001
Neopterin/eGFR ratiob	4.915	1.893–12.758	.001				7.054	2.220–22.418	.001
Neopterin at day 7, nmol/Lb	22.073	2.416–201.652	.006				24.567	2.482–242.174	.006
Neopterin/eGFR ratiob at day 7	8.052	1.683–38.525	.009				11.200	1.746–71.854	.011
Classifications
Neopterin >45 nmol/L vs ≤45 nmol/L	14.548	4.162–50.852	<.001				16.800	4.534–62.252	<.001	7.025	1.161–42.511	.034
Neopterin/eGFR ratio >0.650 vs ≤0.650	6.400	1.772–23.110	.005	25.049	1.123–558.583	.042	5.833	1.615–21.075	.007
IL-6 >80 ng/L vs ≤80 ng/L	68.000	12.472–370.739	<.001	142.956	3.462–5902.918	.009	46.375	10.287–209.059	<.001	7.664	0.500–117.585	.144
CRP >5 mg/dL vs ≤5 mg/dL	9.880	3.125–31.238	<.001	0.319	0.024–4.342	.391	10.789	2.787–41.773	.001	0.581	0.050–6.787	.665

Data depicted in bold indicate significant differences between groups.

Parameters were recorded at day 1 ± 1 if not otherwise depicted. The chi-square test was 37.157 (P < .001) for the multivariate model of ICU admission (n = 67—only patients with all included parameters available) and 24.993 (P < .001) for the multivariate model of need for mechanical ventilation (n = 67—only patients with all included parameters available).

Abbreviations: CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; ICU, intensive care unit; IL-6, interleukin 6; O2, oxygen; OR, odds ratio; PCT, procalcitonin; SpO2, peripheral capillary oxygen saturation.

^aPatients under the age of 70 only (n = 73).

^bLogarithmized because not normally distributed.