Table 2.
Corticosteroids vs baricitinib plus corticosteroids on respiratory function and need of ambulatory supplemental oxygen
| Outcome | Corticosteroids treatment (n = 50) |
Baricitinib and corticosteroids treatment (n = 62) |
P-value |
|---|---|---|---|
| Respiratory function | |||
| SpO2/FiO2 at ED, median (IQR) | 345 (270–410) | 319 (245–405) | 0.372 |
| SpO2/FiO2 on hospitalization, median (IQR) | 155 (122–214) | 154 (128–161) | 0.693 |
| SpO2/FiO2 at discharge, median (IQR) | 410 (332–438) | 442 (428–452) | <0.001 |
| Outcomes | |||
| Change in SpO2/FiO2 from hospitalization to discharge, median (IQR) | 220 (159–284) | 289 (206–308) | 0.002 |
| Patients discharged from hospital requiring supplemental oxygen, n (%) | 31 (62.0) | 16 (25.8) | <0.001 |
| Patients on supplemental oxygen 1 month after discharge, n (%) | 14 (28.0) | 8 (12.9) | 0.046 |
| Differences adjusted for IPSWa | |||
| Change in SpO2/FiO2 from hospitalization to discharge, mean differences (95% CI) | |||
| Unadjusted | 49 (23, 76) | <0.001 | |
| Adjusted for IPSW | 49 (22, 77) | <0.001 | |
| Patients discharged from hospital requiring supplemental oxygen, odds ratio (95% CI) | |||
| Unadjusted | 0.21 (0.10, 0.48) | <0.001 | |
| Adjusted for IPSW | 0.18 (0.08, 0.43) | <0.001 | |
| Patients on supplemental oxygen one month after discharge, odds ratio (95% CI) | |||
| Unadjusted | 0.38 (0.15, 1.00) | 0.050 | |
| Adjusted for IPSW | 0.31 (0.11, 0.86) | 0.024 | |
SpO2/FiO2 on hospitalization: mean of lowest values on three consecutive days.
a
Adjusted for age, sex, diabetes, NEWS, SpO2/FiO2 on hospitalization and high-flow oxygen or non-invasive ventilation (ward), excluding extreme values of IPSW. ED: emergency department; FiO2: fraction of inspired oxygen; IPSW: inverse propensity score weighting; IQR: interquartile range; NEWS: National Early Warning Score; SpO2: oxygen saturation as measured by pulse oximetry.