Table 3.
Distribution of clinician-reported measures in patients with moderate to severe cGvHD
| N (%) | |
|---|---|
| Erythema (BSA%) | |
| 0 | 79 (41) |
| 1–10 | 78 (40) |
| 11–24 | 17 (9) |
| 25–49 | 13 (7) |
| ⩾ 50 | 5 (3) |
| Moveable sclerosis (BSA%) | |
| 0 | 86 (45) |
| 1–10 | 62 (32) |
| 11–24 | 17 (9) |
| 25–49 | 17 (9) |
| ⩾ 50 | 9 (5) |
| Non-moveable sclerosis (BSA%) | |
| 0 | 103 (53) |
| 1–10 | 31 (16) |
| 11–24 | 17 (9) |
| 25–49 | 29 (15) |
| ⩾ 50 | 12 (6) |
| Schirmer w/o anesthesia (mm) | |
| ⩽ 5 | 129 (67) |
| 6–10 | 36 (19) |
| ⩾ 11 | 23 (12) |
| Modified OMRS (0–15) | |
| 0 | 48 (25) |
| 1–2 | 83 (43) |
| 3–10 | 31(16) |
| ⩾ 11 | 1 (0.01) |
| WBC (×103/μl) | |
| ⩽ 3.98 | 20 (10) |
| Normal: 3.99–10.04 | 133 (69) |
| ⩾ 10.05 | 40 (21) |
| Bilirubin (mg/dl) | |
| ⩽ 1.0 | 182 (94) |
| >1.0 | 10 (5) |
| ALT (U/L) | |
| Normal: ⩽ 33 | 86 (45) |
| 34–68 | 71 (37) |
| 69–170 | 25 (13) |
| ⩾ 171 | 10 (5) |
| LFS | |
| 2 | 49 (25) |
| 3–5 | 70 (36) |
| 6–9 | 56 (29) |
| 10–12 | 15 (8) |
| Upper GI Score | |
| 0 | 146 (76) |
| 1 | 34 (18) |
| 2 | 10 (5) |
| 3 | 3 (2) |
| Esophageal Score | |
| 0 | 137 (71) |
| 1 | 37 (19) |
| 2 | 12 (6) |
| 3 | 7 (4) |
| Lower GI Score | |
| 0 | 162 (84) |
| 1 | 22 (11) |
| 2 | 8 (4) |
| 3 | 1 (0.01) |
| Walk distance in 2 min (feet) | |
| ⩽ 500 | 52 (27) |
| 501–650 | 85 (44) |
| ⩾ 651 | 41 (21) |
| Grip strength (lbs) | |
| ⩽ 50 | 88 (46) |
| 51–100 | 87 (45) |
| 101–150 | 10 (5) |
| KPS (%) | |
| 30–60 | 21 (11) |
| 70–80 | 101 (52) |
| 90–100 | 67 (35) |
| 4-point HCP global score | |
| 0 | 1 (0.5) |
| 1 | 38 (20) |
| 2 | 63 (33) |
| 3 | 67 (35) |
| 11-point clinician-assessed global symptom severity score | |
| 0 | 2 (1) |
| 1–3 | 38 (20) |
| 4–6 | 51 (26) |
| 7–8 | 76 (39) |
| 9–10 | 10 (5) |
| Clinician Changea | |
| − 3 | 1 (1) |
| − 2 | 7 (4) |
| − 1 | 53 (27) |
| 0 | 74 (38) |
| +1 | 30 (16) |
| +2 | 8 (4) |
| +3 | 3 (2) |
Abbreviations: BSA: body surface area, w/o: without, OMRS: oral mucosa rating scale, WBC: white blood count, ALT: alanine aminotransferase, LFS: lung function score, GI:gastrointestinal, KPS: Karnofsky performance status, HCP: health care provider.
a
Clinician change in last month: −3: very much worse, −2: moderately worse, −1: a little worse, 0 - about the same, +1: a little better, +2: moderately better, +3: very much better.