| Pedunculation |
Usually present |
May be absent |
| Architecture at low power |
Lobular, round, or smooth contour |
Irregular shape, haphazard distribution |
| Lamina propria around crypts |
May be present |
Absent |
| Connection of deep glands with adenoma |
Can be demonstrated, but may need deeper levels |
May be absent |
| Arrangement of submucosal glands |
Regular |
Haphazard |
| Shape of submucosal glands |
Round and regular |
Irregular with incomplete lumen “abortive” glands |
| Cytology of submucosal glands |
Similar to the superficial aspect of the lesion |
May be worse than superficial aspect of the lesion |
| Hemosiderin |
May be present |
Absent |
| Desmoplasia |
Absent |
Present |
| Small nests or single cells |
Absent |
May be present |
| Mucin pools |
Round, smooth, and may be lined by dysplastic epithelium at periphery |
Irregular contours, and floating cells may be present |
