Table 4. Cutoffs for Fungal Infection (N = 457).

Variable	Best cutoffa	Sensitivityb	Specificityb	Youdenc
MELD	19.33	81.8%	58.6%	40.4%
Total bilirubin	4.20	64.0%	67.8%	31.8%
International normalized ratio	1.50	79.2%	54.8%	33.9%
Hemoglobin	11.30	76.0%	49.8%	25.8%

^aThe value maximizes Youden statistic. ^bROC analysis was performed to derive sensitivity and specificity based on a logistic regression model with the continuous variable of interest (e.g., MELD) as the only covariate. ^cYouden = sensitivity + specificity - 1. MELD: model for end-stage liver disease; ROC: receiver operating characteristic.