Table 6. Association of Iron Therapy With Transfusion Rate.
| Author | Intervention | Transfusion |
||
|---|---|---|---|---|
| Transfusion trigger | Transfusion rate, n/N (%) | Median number of units transfused | ||
| Cladellas et al, 2012 [32] | IV iron + IV EPO | Hb < 7 g/dL | 50/75 (67) | NR |
| Historic observation | 55/59 (93)** | NR | ||
| Urena et al, 2017 [34] | IV iron + IM EPO | Hb < 7 g/dL, Hb 7 - 8 g/dL if symptomatic | 13/48 (27) | 1 |
| Placebo | 13/52 (27) | 2 | ||
| Johansson et al, 2015 [36] | IV | NR | 8/30 (27) | 1 |
| Placebo | 11/30 (37) | 2 | ||
| Padmanabhan et al, 2018 [35] | IV | NR | 16/20 (80) | 1.5 |
| Oral | 12/20 (60) | 2 | ||
| Garrido-Martin et al, 2012 [33] | IV | Hb < 8 g/dL in coronary patients, Hb < 7 g/dL in valve surgery patients | 20/54 (37) | 0 |
| Oral | 27/53 (51) | 1 | ||
| Placebo | 26/50 (50) | 0.5 | ||
| Spahn et al, 2019 [37] | IV + SC EPO | Hb < 7 - 8 g/dL intraoperative and ICU, Hb < 8 g/dL on wards | 108/243 (44) | 0 |
| Placebo | 127/241 (53)* | 1 | ||
*P < 0.05 between groups; **P < 0.001 between groups. Hb: hemoglobin; IV: intravenous; IM: intramuscular; NR: not reported; EPO: Epogen; SC: subcutaneous; ICU: intensive care unit.