Table 1.
Inhibition of virus attachment.
| Target protein | Targeted domain | Name | Virus tested | Sequence derived from | Sequence | Ref (preprint) |
|---|---|---|---|---|---|---|
| Spike protein | RBD | P4 (ACE2 mimics) | SARS-CoV-1 | ACE2 (22–44) | EEQAKTFLDKFNHEAEDLFYQSS | Han et al., 2006 [55] |
| P5 (ACE2 mimics) | ACE2 (22–57) | EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEE | ||||
| RBD | SBP1 | – | ACE2 (21–43) | IEEQAKTFLDKFNHEAEDLFYQS | Zhang et al., 2020 (preprint) [52] | |
| unknown | P2 | SARS-CoV-1 | S Protein (259–278) (SARS-CoV-1) | PTT(K)FMLKYDENGTITDAVDC | Zheng et al., 2005 [56] | |
| P6 | S Protein (598–617) (SARS-CoV-1) | YQDVNCTDVS(P)TAIHADQLTP | ||||
| P8 | S Protein (737–756) (SARS-CoV-1) | QYGSFCT(A)QLNRALSGIAA(V)EQ | ||||
| RBD | AHB1 | SARS-CoV-2 | ACE2 | DEDLEELERLYRKAEEVAKEAKDASRRGDDERAKEQMERAMRLFDQVFELAQELQEKQTDGNRQKATHLDKAVKEAADELYQRVRELEEQVMHVLDQVSELAHELLHKLTGEELERAAYFNWWATEMMLELIKSDDEREIREIEEEARRILEHLEELARK | Cao et al., 2020 [53] | |
| AHB2 | ELEEQVMHVLDQVSELAHELLHKLTGEELERAAYFNWWATEMMLELIKSDDEREIREIEEEARRILEHLEELARK | |||||
| LCB1 | SARS-CoV-2 | de-novo design | DKEWILQKIYEIMRLLDELGHAEASMRVSDLIYEFMKKGDERLLEEAERLLEEVER | |||
| LCB3 | NDDELHMLMTDLVYEALHFAKDEEIKKRVFQLFELADKAYKNNDRQKLEKVVEELKELLERLLS | |||||
| ACE2 | RBD-binding site | RBD-11b | SARS-CoV-1, CoV-NL63 | S Protein RBD (438–443) | YKYRYL | Struck et al., 2012 [67] |
| RBD-binding site (ACE2-Spike interaction sites) | SP-4 (S protein mimics) | SARS-CoV-1 | S Protein (192–203) | GFLYVYKGYQPI | Ho et al., 2006 [68] | |
| SP-8 (S protein mimics) | S Protein (483–494) | FYTTTGIGYQPY | ||||
| SP-10 (S protein mimics) | S Protein (668–679) | STSQKSIVAYTM | ||||
| RBD binding site | S471-503 | SARS-CoV-1 | S Protein RBD (471–503) | ALNCYWPLNDYGFTTTGIGYQPYRVVVLSFEL | Hu et al., 2005 [69] | |
| DX600 | SARS-CoV-1 | peptide library | Ac-GDYSHCSPLRYYPWWKCTYPDPEGGG-NH2 | Huang et al., 2003 [70]; Fukushi et al., 2005 [71] | ||
| RBD binding site | SARS-BLOCK | SARS-CoV-2 | S Protein RBD | unknown | Watson et al., 2020 (preprint) [78] | |
| α5β1 integrin | ACE2 and RBD binding domains | ATN-161 | SARS-CoV-2 | fibronectin | Ac-PHSCN-NH2 | Beddingfield et al., 2020 [74] |