Table 2.

Inhibition of S protein processing.

Target protein	Targeted domain	Name	Virus tested	Sequence derived from	Sequence	Ref (preprint)
TMPRSS2		Aprotinin	SARS-CoV-2	Aprotinin	RPDFC LEPPY TGPCK ARIIR YFYNA KAGLC QTFVY GGCRA KRNNF KSAED CMRTC GGA	Bestle et al., 2020 [84]
	Catalytic site	MI-432	SARS-CoV-2	Protease inhibitor (peptidomimetic)	(S)-3-(3-(4-(2-Aminoethyl)piperidin-1-yl)-2-((2′,4′-dichloro-[1,1′-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide
		MI-1900			(S)-4-(3-(3-Carbamimidoylphenyl)-2-((2′,4′-dimethoxy-[1,1′-biphenyl])-3-sulfonamido)propanoyl)-N-cyclohexylpiperazine-1-carboxamide
Cathepsin L	Enzymatic domain	Teicoplanin	SARS-CoV-2, SARS-CoV-1, MERS-CoV	glycopeptide antibiotic	antibiotic glycopeptide	Zhang et al., 2020 (preprint) [91]
	Acidification	P9	SARS-CoV-2	mouse β-defensin-4	NGAICWGPCPTAFRQIGNCGHFKVRCCKIR	Zhao et al., 2020 [116]
		P9R	SARS-CoV-2	mouse β-defensin-4	NGAICWGPCPTAFRQIGNCGRFRVRCCRIR
		8P9R	SARS-CoV-2, SARS-CoV-1,	mouse β-defensin-4	8 x NGAICWGPCPTAFRQIGNCGRFRVRCCRIR	Zhao et al., 2020 [117]
Furin	Catalytic domain	dec-RVKR-cmk	SARS-CoV-2	PCSK target motif	dec-RVKR-cmk	Cheng et al., 2020 [90,101,190]
	Probably catalytic domain	MI-1851	SARS-CoV-2	Protease inhibitor (peptidomimetic)	(S)-N-((S)-1-((4-Carbamimidoylbenzyl)amino)-4-(guanidinooxy)-1-oxobutan-2-yl)-2-((S)-2-(2-(4-(guanidinomethyl)phenyl)acetamido)-4-(guanidinooxy)butanamido)-3,3-dimethylbutanamide	Bestle et al., 2020 [84]