Table 2. Circulating immune cells and inflammatory markers in patients and controls.
| Cell types | Individuals with CAD | Individuals without atherosclerosis |
|---|---|---|
| WBC (106/mL) | †5.5 [4.9–6.0] | 5.4 [4.8–6.7] |
| Neutrophils (106/mL) | †3.2 [2.5–3.6] | 3.0 [2.6–4.0] |
| Lymphocytes (106/mL) | 1.7 [1.3–1.9] | 1.8 [1.5–2.5] |
| Monocytes (106/mL) | 0.53 [0.42–0.67] | 0.55 [0.45–0.66] |
| Monocytes (%) | 9.8 [8.0–11.5] | 9.3 [7.7–11.1] |
| Classical monocytes (%gated) | 78.1 [72.8–80.3] | 72.8 [70.1–85.5] |
| Intermediate monocytes (%gated) | 9.8 [8.2–14.2] | 10.1 [7.6–13.7] |
| Nonclassical monocytes (%gated) | 12.2 [9.3–14.3] | 13.1 [6.3–18.2] |
| CCR2+ monocytes (%gated) | 80.5 [73.0–82.3] | †77.6 [71.4–86.3] |
| CD11b expression monocytes (MFI) | 10490 [7814–12025]^ | ††6978 [6512–10041] |
| CD41+ monocytes (%gated) | 7.8 [6.5–9.7] | 8.7 [7.6–8.9] |
| Inflammatory markers | ||
| IL-1β (pg/mL) | †0.12 [0.09–0.17] | 0.12 [0.06–0.15] |
| IL-1Ra (pg/mL) | 271 [197-338] | 212 [165-253] |
| IL-6 (pg/mL) | 2.31 [1.37–2.86] | †1.61 [1.23–2.19] |
| IL-18 (pg/mL) | 162 [127-227] | 195 [144-236] |
| hsCRP (pg/mL) | 1.66 [0.83–4.87] | 1.37 [0.53–3.84] |
| E-selectin (ng/mL) | †11.74 [7.65–15.10]* | 8.45 [4.52–14.06] |
| VCAM-1 (ng/mL) | 773 [711-859]^ | 769 [643-844] |
| MMP2 (ng/mL) | 354 [264-434] | 341 [250-427] |
Circulating concentrations of cells and inflammatory markers in individuals with CAD (n = 13) compared to individuals without atherosclerosis (n = 13). Median with [IQR]. P-values are corrected for age and BMI with ANCOVA. Outliers were removed with an SD of >2.5 of Z-scores. † Data is missing for one participant. *p<0.05, **p<0.01. HSPCs: hematopoietic stem and progenitor cells.