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. Author manuscript; available in PMC: 2020 Nov 13.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Apr 23;59(33):13734–13762. doi: 10.1002/anie.201909690

Figure 4.

Figure 4.

Select examples of luminescent ABS probes for biological discovery. a) Chemiluminescent probes based on Schaap’s dioxetane can sense in vivo H2O2 production triggered by LPS[270] as well as formaldehyde by tetrahydrofolate (THF) consumption.[191] b) The bioluminescent probe BP-PN was used to visualize endogenous ONOO− production triggered by liposaccharide (LPS) inflammation.[269] c) The TPA-based probe Copper Caged Luciferin 1 (CCL-1) revealed an early labile CuI deficiency localized to the liver in a diet-induced model of non-alcoholic fatty liver disease (NAFLD), showing more copper accumulation in the liver in mice fed a normal diet (ND) relative to mice fed a high-fat diet (HFD).[232] d) The endoperoxide probe Iron Caged Luciferin 1 (ICL-1) revealed elevations in labile FeII pools upon bacterial infection, correlating increases in labile FeII with sites of higher pathogen burden.[244]